Integrated analysis of competing endogenous RNA networks revealing five prognostic biomarkers associated with colorectal cancer
Integrated analysis of competing endogenous RNA networks revealing five prognostic biomarkers associated with colorectal cancer
复制标题
竞争性内源 RNA 网络的综合分析揭示了与结直肠癌相关的五种预后生物标志物
DOI：
10.1002/jcb.28403
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发表时间：
2019-07-01
影响因子：
4
通讯作者：
Ma, Jie
中科院分区：
文献类型：
--
作者：
Liu, Qian;Deng, Junjie;Ma, Jie
结直肠癌（CRC）是世界范围内发病率和死亡率较高的常见恶性肿瘤。本研究的目的是确定与 CRC 患者总生存 (OS) 显着相关的基因，并预测它们在竞争性内源 RNA (ceRNA) 调控网络中的功能。我们根据 561 名 CRC 患者的癌症基因组图谱数据集中的差异表达 RNA 构建了 lncRNA-miRNA-mRNA 网络。通过单变量 Cox 比例风险回归，从 ceRNA 网络中选择了 12 个差异表达的信使 RNA。然后，使用多元Cox比例风险逐步回归分析这些基因，构建包含5个基因（张力蛋白1、簇蛋白、蛋白脂质蛋白1、上皮调节蛋白和转录因子Spi-B）的预后模型。 Kaplan-Meier 风险生存分析表明，这五基因特征独立预测了 CRC 患者的 5 年总生存率（P
Colorectal cancer (CRC) is a common malignant tumor with high morbidity and mortality around the world. The aim of this study was to determine the genes significantly associated with the overall survival (OS) of CRC patients and predict their function in the competing endogenous RNA (ceRNA) regulation networks. We constructed the lncRNA-miRNA-mRNA networks according to the differentially expressed RNAs from the The Cancer Genome Atlas data sets of 561 CRC patients. Twelve differentially expressed messenger RNAs from the ceRNA networks were selected through a univariate Cox proportional hazards regression. Then, these genes were analyzed by using multivariate Cox proportional hazards stepwise regression to construct a prognostic model in which five genes (tensin 1, clusterin, proteolipid protein 1, epiregulin, and transcription factor Spi-B) were included. The Kaplan-Meier risk survival analysis showed that this five-gene signature independently predicted a 5-year overall survival in CRC patients (P