Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia
Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia
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DOI：
10.1192/bjp.bp.114.156075
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发表时间：
2016-02-01
影响因子：
10.5
通讯作者：
Caniye, Jose M.
中科院分区：
文献类型：
--
作者：
Chen, Yu-Han;Stone-Howell, Breannan;Caniye, Jose M.
研究背景颞叶和额叶慢波delta（1-4 Hz）和theta（4-7 Hz）活动的增加是精神分裂症中报道的最一致的静息态神经异常。额叶与阴性症状和认知能力如注意力有关，阴性症状和注意力受损与功能能力差有关，目的是确定额叶功能障碍是否与功能障碍有关，以减缓为指标，方法收集41名精神分裂症患者和37名健康对照者的闭眼脑磁图数据，和频域源成像本地化的三角洲和θ activity.ResultsElevated三角洲和θ活动在右额叶和右颞顶区观察到精神分裂症与对照组。在精神分裂症中，右额叶三角洲活动与阴性症状而非阳性症状有独特的相关性。在整个样本中，右额叶三角洲活动增加预测较差的注意力和功能capability.ConclusionsOur研究结果表明，治疗相关的慢波活动的减少可能伴随着改善功能的结果，从而更好的预后。
BackgroundIncreased temporal and frontal slow-wave delta (1-4 Hz) and theta (4-7 Hz) activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The frontal lobe is associated with negative symptom's and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity.AimsTo establish whether frontal dysfunction, as indexed by slowing, would be associated with functional impairments.MethodEyes-closed magnetoencephalography data were collected in 41 participants with schizophrenia and 37 healthy controls, and frequency-domain source imaging localised delta and theta activity.ResultsElevated delta and theta activity in right frontal and right temporoparietal regions was observed in the schizophrenia v. control group. In schizophrenia, right-frontal delta activity was uniquely associated with negative but not positive symptoms. In the full sample, increased right-frontal delta activity predicted poorer attention and functional capacity.ConclusionsOur findings suggest that treatment-associated decreases in slow-wave activity could be accompanied by improved functional outcome and thus better prognosis.