Histological alterations in denervated non-regenerating limbs of urodele larvae
Histological alterations in denervated non-regenerating limbs of urodele larvae
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DOI：
10.1002/jez.1400880208
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发表时间：
1941-01-01
影响因子：
--
通讯作者：
Schotté, OE
中科院分区：
文献类型：
--
作者：
Butler, EG;Schotté, OE
以斑点钝口瘤、不透明芽孢杆菌和三灰病毒幼虫为研究对象，比较了非再生神经无力肢体与正常再生组织的组织学变化。去神经支配和截肢导致极端退化，涉及肢体的所有组织结构。无论截肢程度如何，骨骼、肌肉、血管和结缔组织都发生退化，直至近端肩部区域消失。结构单位的退化和消失本质上是细胞去分化的结果，随后是物质的吸收。在完全无神经的断肢上没有胚基。然而，当去分化肢体的神经再生发生时，胚基形成。胚芽形成的地点与截肢的时间或程度没有直接关系。胚芽可以在截肢后很长一段时间内出现在远离截肢水平的点上。胚基被认为是一种结构，它不仅在再生的建立中起作用，而且在正常再生中相关的去分化和分化过程之间保持平衡。
Using larvae of Amblystoma punctatum, A. opacum, and Triturus viri-descens, studies were made on the histological changes in non-regenerating nerveless limbs in comparison with the histology of normal regeneration. Denervation and amputation lead to extreme regression, which involves all organized structures of a limb. Regardless of the level of amputation, skeleton, muscles, blood vessels and connective tissues undergo regression and disappear as far proximally as the shoulder region. Regression and disappearance of structural units is essentially the result of cellular dediffer-entiation, with subsequent resorption of material. No blastema is established on a completely nerveless amputated limb. However, when reinnervation of a dedifferentiating limb takes place, a blastema forms. The point where the blastema is established bears no direct relationship to the time or to the level of amputation. A blastema can arise long after amputation at a point far removed from the level of amputation. The blastema is regarded as a structure which plays a role, not only in the establishment of a regenerate, but also in the maintenance of a balance between the processes of dedifferentiation and differentiation, which are associated in normal regeneration.