The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health.
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health.
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儿童的口腔微生物组：口腔健康以外的发展，疾病及其影响。
DOI：
10.1007/s00248-016-0854-1
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发表时间：
2017-02
影响因子：
3.6
通讯作者：
Nelson KE
中科院分区：
文献类型：
--
作者：
Gomez A;Nelson KE
在应用元组学和个性化医疗时代，口腔微生物组是一项宝贵的资产。从生物标志物的发现到成为治疗靶点的强大来源，再到为开发非侵入性医疗保健方法提供机会，很明显，口腔微生物可能是了解疾病的答案，甚至超越口腔。尽管在过去的50年里，我们对口腔微生物组多样性的理解已经取得了很大进展，但仍有许多领域需要进行微调，以更好地进行风险评估和诊断，特别是在人类生命的早期发育阶段。在这里，我们讨论了影响口腔微生物组发展的因素，并探讨了疾病的口腔标志物，重点是早期口腔。我们的最终目标是将不同的实验和方法观点纳入早期更好地评估早期口腔和全身性疾病的角度，并讨论口腔微生物组如何在社区水平上为个人和高危人群提供更好的评估。
In the era of applied meta-omics and personalized medicine, the oral microbiome is a valuable asset. From biomarker discovery to being a powerful source of therapeutic targets, and to presenting an opportunity for developing non-invasive approaches to health care, it has become clear that oral microbes may hold the answer for understanding disease, even beyond the oral cavity. Although our understanding of oral microbiome diversity has come a long way in the past 50 years, there are still many areas that need to be fine-tuned for better risk assessment and diagnosis, especially in early developmental stages of human life. Here, we discuss the factors that impact development of the oral microbiome, and explore oral markers of disease, with a focus on the early oral cavity. Our ultimate goal is to put different experimental and methodological views into perspective for better assessment of early oral and systemic disease at an early age, and discuss how oral microbiomes- at the community level, could provide improved assessment in individuals, and populations at risk.