Does Prophylactic Administration of Edoxaban Increase D-Dimer Levels after Total Hip Arthroplasty?
Does Prophylactic Administration of Edoxaban Increase D-Dimer Levels after Total Hip Arthroplasty?
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DOI：
10.3390/jcm8050678
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发表时间：
2019-05-01
影响因子：
3.9
通讯作者：
Matsuda, Shuichi
中科院分区：
文献类型：
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作者：
Kawai, Toshiyuki;Kuroda, Yutaka;Matsuda, Shuichi
本研究旨在探讨血栓预防性艾多沙班对全髋关节置换术 (THA) 后 D-二聚体水平和贫血的影响。我们回顾性分析了 349 名接受初次 THA 患者的数据。以术后第7天、第14天和第21天的D-二聚体水平作为因变量，以艾多沙班的使用情况，年龄、性别、体重指数（BMI）、肾功能、血红蛋白（Hb）下降、术中失血量和手术时间作为自变量，进行单因素回归和多因素回归分析。还以 Hb 下降作为因变量进行多变量回归分析。 THA 后给予艾多沙班 15 mg/天和 30 mg/天与术后 21 天较高的 D-二聚体水平相关，但与术后 7 或 14 天无关。高 D-二聚体水平的其他重要独立预测因素包括手术持续时间（第 7 天和 14 天）、BMI（第 7 天）、性别（第 14 天）和年龄（第 14 天和 21 天）。艾多沙班的使用与第 7 天和第 14 天的较大 Hb 下降呈显着、弱相关，但这小于临床上重要的差异。术后三周后，血栓预防性艾多沙班可以升高 THA 后的 D-二聚体水平。
This study aimed to examine the effect of thromboprophylactic edoxaban on D-dimer levels and anemia after total hip arthroplasty (THA). We retrospectively analyzed data from 349 patients undergoing primary THA. Univariate regression and multivariate regression analyses were performed with D-dimer levels on the 7th, 14th, and 21st days postoperatively as the dependent variable Edoxaban use, age, sex, body mass index (BMI), renal function, drop in hemoglobin (Hb) drop, intraoperative blood loss and duration of surgery as were independent variables. Multivariate regression analysis was also performed with Hb drop as the dependent variable. Edoxaban administration of 15 mg/day and 30 mg/day after THA was correlated with higher D-dimer levels at 21, but not at 7 or 14, days postoperatively. Other significant independent predictors for high D-dimer levels were the duration of surgery (at 7 and 14 days), BMI (at 7 days), sex (at 14 days), and age (at 14 and 21 days). Edoxaban use was significantly, weakly correlated with a larger Hb drop at 7 and 14 days, but this was less than a clinically important difference. D-dimer levels after THA can be elevated by thromboprophylactic edoxaban after three weeks postoperatively.