Dietary fiber and serum 16α-hydroxyestrone, an estrogen metabolite associated with lower systolic blood pressure.
Dietary fiber and serum 16α-hydroxyestrone, an estrogen metabolite associated with lower systolic blood pressure.
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膳食纤维和血清16α-羟基雌酮，一种与降低收缩压相关的雌激素代谢物。
DOI：
10.1016/j.nut.2010.08.017
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Masi,ChristopherM
中科院分区：
文献类型：
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作者：
Patel,Shawn;Hawkley,LouiseC;Cacioppo,JohnT;Masi,ChristopherM
目的 我们最近发现绝经后女性的收缩压 (SBP) 与血清 16α-羟基雌酮（17β-雌二醇的代谢产物）之间存在负相关关系。 16α-羟基雌酮的形成主要由 CYP1A2（一种细胞色素 P450 酶）催化。本研究的目的是评估绝经后妇女已知的 CYP1A2 活性调节剂与血清 16α-羟基雌酮之间的关系。我们假设，水果、蔬菜和谷物在总纤维中含有较多的可溶性纤维（一种已知的 CYP1A2 诱导剂），与豆类（在总纤维中所含的可溶性纤维较少）相比，它们与血清 16α-羟基雌酮的相关性更高。 方法 血清来自 42 名 55 至 69 岁绝经后妇女的人群样本 使用质谱法对居住在伊利诺伊州库克县的一名 16α-羟基雌酮进行了检测。在调整多个协变量后，采用序数 Logistic 回归来评估膳食纤维和血清 16α-羟基雌酮之间的横截面关系。 结果与豆类膳食纤维相比，水果和蔬菜中的膳食纤维与较高血清 16α-羟基雌酮浓度的对数比值 (B = 0.201，P = 0.036) 相关。与白人女性相比，非洲裔美国女性血清 16α-羟基雌酮浓度较高的对数几率也较低 (B = −2.300，P = 0.030)。 结论 这些结果与之前的研究一致，即 SBP 与饮食水果和蔬菜之间呈负相关，而非洲裔美国人种族与 SBP 之间呈正相关。需要进一步研究可能影响 16α-羟基雌酮血清浓度的饮食因素。
OBJECTIVEWe recently identified an inverse relation between systolic blood pressure (SBP) and serum 16α-hydroxyestrone, a metabolite of 17β-estradiol, in postmenopausal women. Formation of 16α-hydroxyestrone is catalyzed primarily by CYP1A2, a cytochrome P450 enzyme. The objective of this study was to evaluate the relations between known modifiers of CYP1A2 activity and serum 16α-hydroxyestrone in postmenopausal women. We hypothesized that fruits, vegetables, and grains, which contain more soluble fiber (a known inducer of CYP1A2) as a proportion of total fiber, would be more positively associated with serum 16α-hydroxyestrone than legumes, which contain less soluble fiber as a proportion of total fiber.METHODSSerum from a population-based sample of 42 postmenopausal women 55 to 69 y of age living in Cook County, Illinois, was assayed for 16α-hydroxyestrone using mass spectrometry. Ordinal logistic regression was used to evaluate the cross-sectional relation between dietary fiber and serum 16α-hydroxyestrone after adjusting for multiple covariates.RESULTSCompared with dietary fiber from legumes, dietary fiber from fruits and vegetables was associated with a greater log odds (B = 0.201, P = 0.036) of having higher serum concentrations of 16α-hydroxyestrone. The log odds of having higher serum concentrations of 16α-hydroxyestrone was also lower in African-American women (B = −2.300, P = 0.030) compared with white women.CONCLUSIONThese results are consistent with previous studies demonstrating a negative relation between SBP and dietary fruits and vegetables and a positive relation between African-American race and SBP. Further research is needed regarding dietary factors that may influence the serum concentration of 16α-hydroxyestrone.