Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke
Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke
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DOI：
10.1161/strokeaha.119.028383
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发表时间：
2020-03-01
期刊：
影响因子：
8.3
通讯作者：
Wollenweber, Frank A.
中科院分区：
文献类型：
--
作者：
Tiedt, Steffen;Herzberg, Moriz;Wollenweber, Frank A.
背景和目的：卒中病因驱动血栓组成。因此，我们假设血管内治疗在心脏栓塞性和非心脏栓塞性大血管闭塞（LVOs）中表现出不同的疗效。方法：比较GSR-ET（德国卒中登记-血管内治疗；n=2589）中心栓塞性和非心栓塞性LVO患者出院时和90天的手术特征、再灌注等级和功能结局。为了确定与功能结局的关联，使用调整潜在基线混杂变量的有序多变量逻辑回归模型计算调整后的优势比和95% ci。结果：血管内治疗心脏栓塞性LVO的再灌注成功率更高（85.6%比81.0%；P=0.002），单次取栓通过后的完全再灌注率更高（45.7%比38.1%；P=0.002）
Background and Purpose-Stroke etiology drives thrombus composition. We thus hypothesized that endovascular treatment shows different efficacy in cardioembolic versus noncardioembolic large-vessel occlusions (LVOs).Methods-Procedural characteristics, grade of reperfusion, and functional outcome at discharge and 90 days were compared between patients with cardioembolic versus noncardioembolic LVO from the GSR-ET (German Stroke Registry-Endovascular Treatment; n=2589). To determine associations with functional outcome, adjusted odds ratios and 95% CIs were calculated using ordinal multivariable logistic regression models adjusting for potential baseline confounder variables.Results-Endovascular treatment of cardioembolic LVO had a higher rate of successful reperfusion (85.6% versus 81.0%; P=0.002) and a higher rate of complete reperfusion after a single thrombectomy pass (45.7% versus 38.1%; P