Iota-Carrageenan is a potent inhibitor of rhinovirus infection.
Iota-Carrageenan is a potent inhibitor of rhinovirus infection.
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DOI：
10.1186/1743-422x-5-107
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发表时间：
2008-09-26
期刊：
影响因子：
4.8
通讯作者：
Unger H
中科院分区：
文献类型：
--
作者：
Grassauer A;Weinmuellner R;Meier C;Pretsch A;Prieschl-Grassauer E;Unger H
人类鼻病毒（HRV）是普通感冒的主要原因。此外，HRV 还与慢性阻塞性肺病和哮喘的恶化以及肺移植的失败有关。尽管付出了巨大的努力，但尚未有抗病毒药物被批准用于预防或治疗 HRV 感染。在这项研究中，我们证明 Iota-卡拉胶（一种源自红海藻的硫酸化多糖）是一种有效的体外抗鼻病毒物质。 Iota-卡拉胶可降低 HRV 生长并抑制病毒诱导的受感染 HeLa 细胞的细胞病变效应。此外，Iota-卡拉胶可有效防止 HRV1A、HRV2、HRV8、HRV14、HRV16、HRV83 和 HRV84 在培养的原代人鼻上皮细胞中的复制。数据表明，Iota-卡拉胶主要通过阻止病毒粒子结合或进入细胞来发挥作用。由于 HRV 感染主要发生在鼻腔和上呼吸道，因此可以使用含有 Iota-卡拉胶的产品进行针对性治疗。需要进行临床试验来确定基于 Iota-卡拉胶的产品是否能有效治疗或预防 HRV 感染。
Human rhinoviruses (HRVs) are the predominant cause of common cold. In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the loss of lung transplants. Despite significant efforts, no anti-viral agent is approved for the prevention or treatment of HRV-infection. In this study we demonstrate that Iota-Carrageenan, a sulphated polysaccharide derived from red seaweed, is a potent anti-rhinoviral substance in-vitro. Iota-Carrageenan reduces HRV growth and inhibits the virus induced cythopathic effect of infected HeLa cells. In addition, Iota-Carrageenan effectively prevents the replication of HRV1A, HRV2, HRV8, HRV14, HRV16, HRV83 and HRV84 in primary human nasal epithelial cells in culture. The data suggest that Iota-Carrageenan acts primarily by preventing the binding or the entry of virions into the cells. Since HRV infections predominately occur in the nasal cavity and the upper respiratory tract, a targeted treatment with a product containing Iota-Carrageenan is conceivable. Clinical trials are needed to determine whether Iota-Carrageenan-based products are effective in the treatment or prophylaxis of HRV infections.