Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement
Preparation and characterization of an oridonin nanosuspension for solubility and dissolution velocity enhancement
复制标题
冬凌草甲素纳米混悬剂的制备和表征，以提高溶解度和溶解速度
DOI：
10.1080/03639040701741810
复制
发表时间：
2007-01-01
影响因子：
3.4
通讯作者：
Wang, Shumei
中科院分区：
文献类型：
--
作者：
Gao, Lei;Zhang, Dianrui;Wang, Shumei
研究了高压均质法制备冬凌草甲素（ORI）纳米混悬液。目的是获得稳定的纳米混悬液，增加药物饱和溶解度和溶解速度。从粒度和长期稳定性方面对均质化工艺进行了优化。对脱水后的冬凌草甲素纳米悬浮液的粒径、粒径分布、形状和zeta电位等特性进行了评价。通过溶解度和溶出度实验，验证了与商业ORI相比，其溶出行为有明显改善。最后，通过差示扫描量热法（DSC）和粉末x射线（PXRD）对配方前后的结晶状态进行评价。
This study describes the preparation of an oridonin (ORI) nanosuspension by high-pressure homogenization (HPH). The aim was to obtain a stable nanosuspension with an increased drug saturation solubility and dissolution velocity. The homogenization procedure was optimized in regard to particle size and long-term stability. The characteristics of the oridonin nanosuspension, such as particle size, size distribution, shape, and zeta potential, were evaluated following the water removal. The solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with commercial ORI. Finally, crystalline state evaluation before and following the formulation was performed through differential scanning calorimetry (DSC) and powder X-ray (PXRD).