Prognostic value of lymphovascular space invasion determined with hematoxylin-eosin staining in early stage cervical carcinoma: results of a multivariate analysis
Prognostic value of lymphovascular space invasion determined with hematoxylin-eosin staining in early stage cervical carcinoma: results of a multivariate analysis
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DOI：
10.1093/annonc/mdg412
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发表时间：
2003-10-01
影响因子：
50.5
通讯作者：
Castaigne, D
中科院分区：
文献类型：
--
作者：
Morice, P;Piovesan, P;Castaigne, D
背景资料：我们的目的是研究IB期和II期宫颈癌患者初次手术治疗时淋巴血管间隙浸润（LVSI）的预后价值。患者和方法：回顾性分析了1985年至1998年期间接受手术的193例患者，对于IB期（180例患者）或II期（13例患者）宫颈癌，采用中线剖腹术进行初始根治性子宫切除术和盆腔（+/-主动脉旁）淋巴结切除术。结果：LVSI的发生率与肿瘤分期、淋巴结状态及阳性淋巴结的位置有关。使用单变量分析，肿瘤大小（
Background: Our aim was to study the prognostic value of the presence of lymphovascular space invasion (LVSI) in patients with stage IB and II cervical carcinoma treated by initial surgery.Patients and methods: A retrospective analysis was performed on 193 patients who underwent, between 1985 and 1998, an initial radical hysterectomy with pelvic (+/-para-aortic) lymphadenectomy using midline laparotomy for stage IB (180 patients) or II (13 patients) cervical carcinoma. Postoperative therapy was delivered according to prognostic factors.Results: The rate of LVSI correlated significantly with tumor stage, nodal status and the location of positive nodes. Using univariate analysis, tumor size (