Presynaptic Cholinergic Dysfunction in Patients with Dementia
Presynaptic Cholinergic Dysfunction in Patients with Dementia
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DOI：
10.1111/j.1471-4159.1983.tb11311.x
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发表时间：
1983-02
影响因子：
4.7
通讯作者：
N. Sims;D. Bowen;S. J. Allen;C. C. Smith-C.;D. Neary;D. J. Thomas;A. Davison
中科院分区：
文献类型：
--
作者：
N. Sims;D. Bowen;S. J. Allen;C. C. Smith-C.;D. Neary;D. J. Thomas;A. Davison
摘要：对老年痴呆患者新皮层活检标本突触前胆碱能神经末梢指标进行了检测。对于组织学证实阿尔茨海默病的患者，[14C]乙酰胆碱合成、胆碱乙酰转移酶活性和胆碱摄取均明显降低（至少40%），低于平均对照值。额叶和颞叶的样品都发生了变化，在神经元活动高和低的条件下，[14C]乙酰胆碱合成的减少是相似的（分别在31毫米和5毫米K+中孵卵评估）。未检测到阿尔茨海默病组织学特征的其他痴呆患者的样本产生了与对照组相似的所有三个生化参数的值。对于整个老年痴呆患者组来说，突触前胆碱能神经末梢的三个标记值之间存在相关性，这表明阿尔茨海默病患者这些部位的功能活动丧失。
Abstract: Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia. For those patients in whom Alzheimer's disease was histologically confirmed, [14C]acetylcholine synthesis, choline acetyltransferase activity and choline uptake were all found to be markedly reduced (at least 40%) below mean control values. The changes occurred in samples from both the frontal and temporal lobes and for [14C]acetylcholine synthesis the decrease was similar under conditions of high and low neuronal activity (as assessed by incubations in 31 mM and 5 mM K+ respectively). Samples from other demented patients, in whom the histological features of Alzheimer's disease were not detected, produced values for all three biochemical parameters which were similar to controls. For the total group of patients with presenile dementia there were correlations between values for the three markers of presynaptic cholinergic nerve endings suggestive of a loss of functional activity at these sites in Alzheimer's disease.