NEUROPATHOLOGY AND APOLIPOPROTEIN-E PROFILE OF AGED CHIMPANZEES - IMPLICATIONS FOR ALZHEIMER-DISEASE
NEUROPATHOLOGY AND APOLIPOPROTEIN-E PROFILE OF AGED CHIMPANZEES - IMPLICATIONS FOR ALZHEIMER-DISEASE
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DOI：
10.1073/pnas.91.20.9382
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发表时间：
1994-09-27
影响因子：
11.1
通讯作者：
MIRRA, SS
中科院分区：
文献类型：
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作者：
GEARING, M;REBECK, GW;MIRRA, SS
将三只老年黑猩猩的神经病理学结果与恒河猴和阿尔茨海默病患者的神经病理学结果进行了比较。非人类灵长类动物的老年斑和血管对淀粉样β蛋白和载脂蛋白E (apoE) 具有免疫反应性，概括了人类衰老和阿尔茨海默病的发现。阿尔茨海默病的另一个标志——神经原纤维缠结不存在。黑猩猩的 PCR/限制性酶分析揭示了与人类 APOE 4 型等位基因相似的 APOE 谱，与阿尔茨海默病风险增加相关。这些发现推翻了 APOE 3 型等位基因的缺失容易形成神经原纤维缠结的假设，并支持老年灵长类动物在探索淀粉样蛋白加工机制和 apoE 的作用方面的价值。
Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease. Neurofibrillary tangles, another hallmark of Alzheimer disease, were absent. PCR/restriction-enzyme analysis in chimpanzees revealed an APOE profile similar to the human APOE type 4 allele associated with an increased risk of Alzheimer disease. These findings militate against the hypothesis that the absence of APOE type 3 allele predisposes to neurofibrillary tangle formation and support the value of aged primates for exploring mechanisms of amyloid processing and the role of apoE.