TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway
TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway
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TRIM31通过Akt信号通路促进胶质瘤细胞增殖、侵袭和迁移
DOI：
10.4149/neo_2019_190106n21
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发表时间：
2019-01-01
期刊：
影响因子：
3
通讯作者：
Wang, D.
中科院分区：
文献类型：
--
作者：
Shi, G.;Lv, C.;Wang, D.
本研究旨在探讨TRIM 31在胶质瘤中的作用。免疫组化和western blot分析显示TRIM 31在高级别胶质瘤组织中过表达。单因素生存分析显示TRIM31高表达与胶质瘤患者生存期短有关。多因素生存分析显示TRIM31是胶质瘤患者的独立预后因素。此外，通过对胶质瘤细胞系的实验，我们发现沉默或过表达TRIM31后，胶质瘤细胞的增殖、侵袭和迁移能力可通过Akt信号通路下调或上调。总之，我们的研究表明TRIM31可能是胶质瘤干预的有效靶点。
This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma patients. Multivariate survival analysis demonstrated that TRIM31 was an independent prognostic factor for glioma patients. In addition, through the experiments on glioma cell lines, we found that after silencing or overexpressing TRIM31 expression, the proliferation, invasion and migration of glioma cells could be downregulated or upregulated through Akt signaling pathway. In short, our study suggests that TRIM31 may be an effective target for glioma intervention.