RHINOVIRUS ASSOCIATED WITH SEVERE LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN
RHINOVIRUS ASSOCIATED WITH SEVERE LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN
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DOI：
10.1097/inf.0b013e31818ffc1b
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发表时间：
2009-04-01
影响因子：
3.6
通讯作者：
Schnurr, David P.
中科院分区：
文献类型：
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作者：
Louie, Janice K.;Roy-Burman, Arup;Schnurr, David P.
Rhinovirus is a respiratory virus most typically associated with the common cold and asthma exacerbations, and has not traditionally been considered to play a major role in severe lower respiratory tract infections (LRTIs). As part of a surveillance program for respiratory pathogens of public health importance, children consecutively admitted to intensive care for LRTI at a large tertiary children's hospital were tested with polymerase chain reaction for I I respiratory viruses and Mycoplasma pneumoniae from February 21 to October 31, 2007; 43 cases were enrolled and rhinovirus was the most frequently detected pathogen, with 21 (49%) positive. Rhinovirus cases frequently were young (median age, 1.4 years [range, 44 days-15 years]), hospitalized for pneumonia (10; 48%), had chronic underlying illnesses (15; 71%), had abnormal chest radiographs (18; 86%), required mechanical ventilation (12; 57%), and had prolonged hospitalization (median length, 7 days [range, 1-29 days]). Coinfection with other viruses or bacteria was common (10; 47%). Rhinovirus may be associated with more severe LRTI in children than previously reported, particularly in the noninfluenza, nonrespiratory syncytial virus season.
