INTRACELLULAR GROWTH OF HISTOPLASMA CAPSULATUM
INTRACELLULAR GROWTH OF HISTOPLASMA CAPSULATUM
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DOI：
10.1128/jb.89.2.518-523.1965
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发表时间：
1965-01-01
影响因子：
3.2
通讯作者：
HOWARD, DH
中科院分区：
文献类型：
--
作者：
HOWARD, DH
在各种实验条件下，哺乳动物组织细胞中荚膜组织浆的生成时间具有显著的稳定性。5株荚膜荚膜孢子虫的胞内生长速率非常相似。在相同条件下，真菌在豚鼠细胞内的产生时间与在小鼠细胞内的产生时间几乎相同。在小鼠组织细胞吞噬后的前24小时内，酵母细胞初步暴露于特异性抗体和补体并不影响真菌的细胞内增殖。在免疫小鼠和豚鼠的细胞内，真菌的生长速度与正常动物的细胞相当。后一种结果没有被真菌初步暴露于高免疫血清和补体而改变。
Under a variety of experimental conditions, the generation time of Histoplasma capsulatum in mammalian histiocytes was remarkably constant. The rate of intracellular growth of five different isolates of H. capsulatum was very similar. The generation time of the fungus within guinea pig cells was nearly the same as it was within mouse cells under comparable conditions. Preliminary exposure of yeast cells to specific antibodies and complement did not affect intracellular proliferation of the fungus during the first 24 hr after phagocytosis by mouse histiocytes. The rate of growth of the fungus within cells from immunized mice and guinea pigs was comparable to that in cells from normal animals. This latter result was not altered by preliminary exposure of the fungus to hyperimmune serum and complement.