Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population.
Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population.
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DOI：
10.1038/nutd.2017.14
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发表时间：
2017-04-10
影响因子：
6.1
通讯作者：
Tzoulaki I
中科院分区：
文献类型：
--
作者：
Al-Dabhani K;Tsilidis KK;Murphy N;Ward HA;Elliott P;Riboli E;Gunter M;Tzoulaki I
尽管卡塔尔和中东其他地区的阳光时间很长，但维生素D缺乏症一直在上升。与此同时，卡塔尔的代谢综合征患病率也一直在上升。维生素D水平与代谢综合征有关，但数据不一致，而且没有研究表明这些疾病在中东人群中的高患病率之间的相互关系。目的是调查卡塔尔生物库人群中维生素D缺乏的患病率及其与代谢综合征及其组成部分的关系。卡塔尔生物库的1205名参与者(702名女性和503名男性)，年龄在18岁到80岁之间，包括卡塔尔人和非卡塔尔人，他们进行了一项横断面研究，对年龄、性别、种族、采血季节、体力活动和教育进行了调整，以检验代谢综合征和维生素D缺乏患病率(定义为20 ng ml−1血清维生素D水平)之间的关系。计算所有分析的优势比和95%可信区间。约%的受试者患有维生素D缺乏(20 ng ml−1)，男性(68.6%)多于女性(61.3%)。代谢综合征患者的血清维生素D水平比非代谢综合征患者低8%(RR：0.92，95%CI：0.87~0.98，P值：0.01)。腰围和高密度脂蛋白以及高甘油三酯水平也与维生素D缺乏显著正相关。没有发现代谢综合征或糖尿病的其他组成部分与维生素D缺乏症之间存在关联。维生素D缺乏症在卡塔尔人中很普遍。代谢综合征的出现与维生素D缺乏有关。未来需要进行前瞻性研究，以调查因果关系的可能性。
Despite long hours of sunlight in Qatar and other regions of the Middle East, vitamin D deficiency has been rising. In parallel, the prevalence of metabolic syndrome has also been increasing in Qatar. Vitamin D levels have been associated with metabolic syndrome but the data are inconsistent and no studies have addressed these inter-relationships in a Middle Eastern population where the prevalence of these conditions is high. The objective is to investigate the prevalence of vitamin D deficiency and its association with metabolic syndrome and its components in the Qatar Biobank population. A cross-sectional study of 1205 participants (702 women and 503 men) from the Qatar Biobank, comprising Qataris and non-Qataris between the ages of 18 and 80 years, was used to perform multivariate linear regression analyses to examine the association between metabolic syndrome and prevalence of vitamin D deficiency (defined as <20 ng ml−1 serum vitamin D levels) adjusting for age, sex, ethnicity, season of blood collection, physical activity and education. Odds ratios and 95% confidence intervals were calculated for all analyses. Approximately 64% of participants were vitamin D deficient (<20 ng ml−1) with more men being deficient (68.6%) than women (61.3%). Serum vitamin D was 8% lower in individuals with metabolic syndrome (RR: 0.92, 95%CI: 0.87–0.98, P-value: 0.01) compared to individuals without metabolic syndrome. Waist circumference and HDL as well as high triglyceride levels were also significantly positively associated with vitamin D deficiency. No association was found between the other components of metabolic syndrome or diabetes and the presence of vitamin D deficiency. Vitamin D deficiency is prevalent in this Qatari population. Presence of metabolic syndrome was associated with presence of vitamin D deficiency. Future prospective studies need to be conducted to investigate the potential for causality.