Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA)
Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA)
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DOI：
10.1002/gps.2409
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发表时间：
2010-07-01
影响因子：
4
通讯作者：
Kendig, Hal
中科院分区：
文献类型：
--
作者：
Atlantis, Evan;Browning, Colette;Kendig, Hal
目的：糖尿病可能与抑郁症和抗抑郁药物（ADM）的使用有关，但已发表的研究结果仍然模棱两可。作者的目的是确定与基线抑郁暴露（症状和/或ADM使用）相关的糖尿病发病率风险。方法：前瞻性队列研究在非机构的澳大利亚老年人（N = 1000, 65岁以上）的区域代表性样本中进行，他们在1994年至2004年期间每两年随访一次（损失率约为24%）。通过自我报告或特定药物来确定，分析排除了基线时普遍存在糖尿病的参与者。糖尿病发病率在任何随访阶段均由首次自我报告确定。抑郁暴露（基线预测因子）由老年心理评估量表（PAS）抑郁量表和ADM使用定义，并分类为：(1)“有症状”（PAS评分5+）；(2)“ADM使用”；(3)“症状性或ADM使用”；(4)“有症状且未使用ADM”；(5)无症状（PAS评分）
Objective: Diabetes may be associated with depression and antidepressant medication (ADM) use, but published findings remain equivocal. The authors' aimed to determine the risk of diabetes incidence associated with baseline depression exposures (symptoms and/or ADM use).Methods: A prospective cohort study was conducted in a regionally representative sample of non-institutionalised older Australian people (N = 1000, aged 65 + year), who were followed up biennially between 1994 and 2004 (attrition was approximate to 24%). Analyses excluded participants for prevalent diabetes at baseline, determined by self-report or specific medications. Diabetes incidence was ascertained by first self-report at any follow-up wave. Depression exposures (baseline predictors) were defined by the Psychogeriatric Assessment Scales (PAS) depression scale and ADM use, and classified as: (1) 'symptomatic' (PAS score 5+); (2) 'ADM use'; (3) 'symptomatic or ADM use'; (4) 'symptomatic and no ADM use'; (5) 'asymptomatic (PAS score