Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
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DOI：
10.1016/j.radonc.2005.10.002
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发表时间：
2005-11-01
影响因子：
5.7
通讯作者：
Langendijk, JA
中科院分区：
文献类型：
--
作者：
Jellema, AP;Doornaert, P;Langendijk, JA
背景和目的：研究平均唾液腺和口腔剂量与中重度口干和粘性唾液的关系。患者和方法：157例接受双侧放射治疗的头颈部癌症患者。CT扫描勾画出腮腺、颌下腺和口腔。结果：在6个月时，平均腮腺(MDPAR)和平均下颌下剂量(MDsubm)与口干症之间存在显著的相关性(OR-MDPAR：1.17；P=0.002；OR-MDsubm：1.08；P=0.02)。在MDpar和MDsubm之间，存在一个重要的相互作用项。没有发现与口腔剂量有显著关联。口干症是可逆的，取决于MDpar和MDsubm。考虑到唾液粘稠，6个月和12个月时发现MDsubm与MDsubm显著相关(OR：1.03；P
Background and Purpose: To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva.Patients and methods: One hundred and fifty-seven patients treated with bilateral irradiation for head and neck cancer were included. The parotid and submandibular glands and the oral cavity were delineated on plannings-CT scans. At baseline and 6 and 12 months self-reported xerostomia and sticky saliva were assessed using the EORTC QLQ-H&N35 questionnaire.Results: At 6 months a significant association between the mean parotid (MDpar) and mean submandibular dose (MDsubm) and xerostomia was observed (OR-MDpar: 1.17; P=0.002 and OR-MDsubm: 1.08; P=0.02). Between MDpar and MDsubm, a significant interaction term was present. No significant association was found with the oral cavity dose. Xerostomia was reversible depending on MDpar and MDsubmConsidering Sticky saliva, a significant association was found at 6 and 12 months with MDsubm (OR: 1.03; P