Does body size contribute to sensitivity of bone tumor induction by radionuclide exposure?
Does body size contribute to sensitivity of bone tumor induction by radionuclide exposure?
复制标题
体型大小是否会影响放射性核素暴露诱导骨肿瘤的敏感性？
DOI：
10.1097/00004032-200008000-00015
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发表时间：
2000
期刊：
影响因子：
2.2
通讯作者：
Miller,SC
中科院分区：
文献类型：
--
作者：
Lloyd,RD;Taylor,GN;Miller,SC
调查的可能增加的灵敏度发生放射性核素诱导的骨骼恶性肿瘤的增加，身体的大小进行了分析之间的358比格犬注射作为年轻的成年人与226 Ra或单体239钚，并保持其寿命。相应的分析进行了约240其他比格犬注射作为年轻的成年人与90 Sr，228 Ra，或228 Th。注射时的体重范围为约5.6至16 kg。Logistic回归分析使用体重和累积骨骼辐射剂量作为自变量表明，不能建立肿瘤的发生依赖于体重，虽然骨骼剂量被发现与骨癌的发生显着相关。回归分析表明，对于任何剂量组，都不能确定体重与骨骼剂量之间的相关性。将每种核素具有相似注射kBq kg− 1的每个剂量组分为2个大小相等的亚组，一个亚组包含体重较小的犬，另一个亚组包含体重较大的犬。通过Fisher精确检验比较了骨骼剂量率大致均匀值内的这些亚组，并使用相同方法将每个核素中质量较小的亚组与组合的质量较大的亚组进行了额外的单独分析。仅在一种情况下（给予3607 kBq 90 Sr kg− 1的剂量组），在更大的亚组中，犬的肿瘤发生率显著更高（p= 0.061）。然而，对于给予0.382 kBq 239 Pu kg− 1的组，亚组之间存在显著差异，但效果与最高水平90 Sr犬的结果完全相反，因为较小的亚组比最大的亚组具有更高的相对肿瘤发生率（p= 0.042）。对于p值< 0.10的所有组，研究了注射时存活率和体重之间可能的相关性（因为骨肿瘤发生可能是寿命的函数），但无法确定显著关系。对于任何放射性核素，合并的质量较大的亚组和合并的质量较小的亚组之间没有显著差异。我们的结论是，在我们的实验条件下，一个物种内的相对大小并没有重要贡献的敏感性（终身发生）诱导骨骼恶性肿瘤。
Investigation of a possible increase in sensitivity to occurrence of radionuclide-induced skeletal malignancy with increasing body size was analyzed among 358 beagles injected as young adults with either 226 Ra or monomeric 239 Pu and maintained for their lifespans. Corresponding analyses were performed for about 240 other beagles injected as young adults with 90 Sr, 228 Ra, or 228 Th. Body masses at the time of injection ranged between about 5.6 and 16 kg. Logistic regression analysis using body mass and cumulative skeletal radiation dose as the independent variables indicated that there could not be established a dependency of tumor occurrence upon body mass, although skeletal dose was found to be significantly correlated with occurrence of bone cancer. Regression analysis indicated that for any dosage group there could not be established a correlation between body mass and skeletal dose. Each dosage group having similar injected kBq kg− 1 for each nuclide was divided into 2 subgroups of equal size, one containing the less massive dogs and the other containing the more massive dogs. These subgroups within a roughly uniform value of skeletal dose-rate were compared by Fisher's Exact Test, and the less massive subgroups were combined within each nuclide for an additional, separate analysis against the combined more massive subgroups using the same method. In only one instance (the dosage group given 3607 kBq 90Sr kg− 1) was there indicated a substantially greater tumor occurrence among dogs in the more massive subgroup (p= 0.061). However, for the group given 0.382 kBq 239Pu kg− 1 there was indicated a significant difference between subgroups, but the effect was exactly opposite to that found for the highest level 90Sr dogs in that the less massive subgroup had a higher relative tumor occurrence than the most massive (p= 0.042). For all groups with a p-value< 0.10, a possible correlation was investigated between survival and body mass at injection (since bone tumor occurrence might be a function of longevity), but a significant relationship could not be determined. No significant differences could be established between the combined more massive and the combined less massive subgroups for any radionuclide. We conclude that, for the conditions in our experiment, relative size within a species does not contribute importantly to the sensitivity (lifetime occurrence) for induction of skeletal malignancy.