Clinical Use of a Bioartificial Liver in the Treatment of Acetaminophen-Induced Fulminant Hepatic Failure
Clinical Use of a Bioartificial Liver in the Treatment of Acetaminophen-Induced Fulminant Hepatic Failure
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生物人工肝治疗对乙酰氨基酚引起的暴发性肝衰竭的临床应用
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
A. Demetriou
中科院分区：
文献类型：
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作者：
O. Detry;N. Arkadopoulos;Paul P Ting;E. Kahaku;F. Watanabe;J. Rozga;A. Demetriou
符合国王学院医院标准的对乙酰氨基酚诱发的暴发性肝衰竭（FHF）患者如果不接受肝移植，死亡风险很高（bbb90 %）。我们已经为这些患者开发了一种基于体外生物人工肝（BAD）支持系统的治疗策略。在这项研究中，我们报告了BAL支持在对乙酰氨基酚诱发的FHF患者中的临床应用结果。所有患者均被送入专门的外科重症监护病房。对患者进行紧急肝移植评估，并接受标准医疗措施，包括n -乙酰半胱氨酸治疗和颅内压监测。此外，他们每天接受6小时的BAL治疗。8例患者接受了治疗。3例患者接受肝移植，5例患者无需移植即可康复。所有患者在BAL支持系统治疗后均有神经和代谢改善。即使在没有肝移植的情况下，BAL支持系统似乎也能改善对乙酰氨基酚诱导的FHF高危患者的预后。在器官短缺和移植成本高的时代，避免肝移植尤为重要。
Patients with acetaminophen-induced fulminant hepatic failure (FHF) who meet the King's College Hospital criteria have a high mortality risk (>90%) if they do not undergo liver transplantation. We have developed a treatment strategy for these patients based on the use of an extracorporeal bioartificial liver (BAD support system. In this study, we report the results of the clinical application of BAL support in patients with acetaminophen-induced FHF. All patients were admitted to a dedicated surgical intensive care unit. They were evaluated for urgent liver transplantation and received the standard medical measures, including N-acetylcysteine administration and intracranial pressure monitoring. Moreover, they underwent daily 6-hour BAL treatments. Eight patients were treated. Three patients were bridged to liver transplantation, and five patients recovered without a transplant. All patients experienced neurological and metabolic improvement after treatments with the BAL support system. The BAL support system seems to improve the outcome of high-risk patients with acetaminophen-induced FHF, even in the absence of liver transplantation. Avoiding liver transplantation is particularly important in an era of organ shortage and high cost of transplants.
生物人工肝治疗严重肝衰竭的临床经验。
影响因子：
9
作者：
Watanabe,FD;Mullon,CJ;Hewitt,WR;Arkadopoulos,N;Kahaku,E;Eguchi,S;Khalili,T;Arnaout,W;Shackleton,CR;Rozga,J;Solomon,B;Demetriou,AA
通讯作者：
Demetriou,AA