Night shift work and levels of 6-sulfatoxymelatonin and cortisol in men.
Night shift work and levels of 6-sulfatoxymelatonin and cortisol in men.
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DOI：
10.1158/1055-9965.epi-12-1377
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Davis S
中科院分区：
文献类型：
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作者：
Mirick DK;Bhatti P;Chen C;Nordt F;Stanczyk FZ;Davis S
夜班工作与男性癌症有关，但生物学机制尚不清楚。我们调查了男性夜班工人是否表现出褪黑激素和皮质醇水平的变化，这是癌症风险的潜在生物标志物。尿液收集185夜班和158日班工作的男性医疗保健提供者，年龄22-55岁，整个工作和睡眠期间，并测定6-硫酸氧褪黑激素和皮质醇。在晚上结束后90分钟内收集早晨血清，并测定皮质醇。夜班工作者在白天睡眠、夜间工作和非夜班夜间睡眠时6-硫酸酯基褪黑激素水平显著降低（分别低57%，62%和40%），相对于白天工作者在夜间睡眠（p<0.0001）;夜班工人的尿皮质醇在白天睡眠时高16%，在非夜班的夜间睡眠时低13%（p<0.05）。夜班工人早晨血清皮质醇工作后和睡眠后分别比白班工人睡眠后水平低24%和43%（p<0.0001）。夜班工人的受试者内比较显示，相对于夜间睡眠，白天睡眠和夜间工作期间的褪黑激素水平显着降低，尿皮质醇水平显着升高（p<0.01）;工作后的早晨血清皮质醇水平低于睡眠后的水平。夜班工人在夜间工作和白天睡眠期间的6-硫酸酯基褪黑激素水平明显较低，夜班工人在夜间睡眠时的水平仍然很低。夜班工人褪黑激素的慢性减少可能是一个重要的致癌机制。皮质醇分泌模式可能会受到夜班工作的影响，这可能会影响癌症风险。轮班可能是许多类型癌症的重要风险因素。
Nightshift work is associated with cancer among men, but the biological mechanism is unclear. We investigated whether male nightshift workers demonstrated changes in levels of melatonin and cortisol, potential biomarkers of cancer risk. Urine was collected from 185 nightshift and 158 dayshift-working male healthcare providers, aged 22-55, throughout work and sleep periods and assayed for 6-sulfatoxymelatonin and cortisol. Morning serum was collected within 90 minutes of completing the night and assayed for cortisol. Nightshift workers had significantly lower 6-sulfatoxymelatonin levels during daytime sleep, nighttime work, and nighttime sleep on off-nights (57%, 62% and 40% lower, respectively), relative to the dayshift workers during nighttime sleep (p<0.0001); urinary cortisol in nightshift workers was 16% higher during daytime sleep and 13% lower during nighttime sleep on off-nights (p<0.05). Morning serum cortisol post-work and post-sleep in nightshift workers were 24% and 43% lower, respectively, than post-sleep levels among dayshift workers (p<0.0001). Within-subject comparisons among the nightshift workers revealed significantly lower melatonin levels and significantly higher urinary cortisol levels during daytime sleep and nighttime work, relative to nighttime sleep (p<0.01); morning serum cortisol levels post-work were lower than those post-sleep. Nightshift workers have substantially lower 6-sulfatoxymelatonin during night work and daytime sleep, and levels remain low when nightshift workers sleep at night. Chronic reduction in melatonin among nightshift workers may be an important carcinogenic mechanism. Cortisol secretion patterns may be impacted by night shift work, which could affect cancer risk. Shiftwork could be an important risk factor for many types of cancer.