WHAT SYMPTOMS PREDICT THE BRONCHIAL RESPONSE TO HISTAMINE - EVALUATION IN A COMMUNITY SURVEY OF THE BRONCHIAL SYMPTOMS QUESTIONNAIRE (1984) OF THE-INTERNATIONAL-UNION-AGAINST TUBERCULOSIS-AND-LUNG-DISEASE
WHAT SYMPTOMS PREDICT THE BRONCHIAL RESPONSE TO HISTAMINE - EVALUATION IN A COMMUNITY SURVEY OF THE BRONCHIAL SYMPTOMS QUESTIONNAIRE (1984) OF THE-INTERNATIONAL-UNION-AGAINST TUBERCULOSIS-AND-LUNG-DISEASE
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DOI：
10.1093/ije/18.1.165
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发表时间：
1989-03-01
影响因子：
7.7
通讯作者：
PAPACOSTA, AO
中科院分区：
文献类型：
--
作者：
BURNEY, PGJ;CHINN, S;PAPACOSTA, AO
由国际结核病和肺病联合会（IUATLD）开发的评估支气管症状的问卷调查表已被用于预测生活在英格兰南部两个地区的18-64岁成年人对组胺的支气管反应的能力。在第一个随机选择的一半受试者中，发现一些问题与反应性增加独立相关。这些症状包括喘鸣、夜间醒来呼吸急促、胸闷或呼吸急促（当暴露于动物、灰尘或羽毛时）以及持续呼吸问题的非特异性症状。基于这些症状的预测评分在预测后半部分受试者对组胺的反应方面比单独的喘息问题更敏感，特异性仅略低。关于哮喘的问题虽然更具体，但比这两个问题敏感得多。症状没有区分与阳性皮肤试验相关的反应和与吸烟相关的反应。
A questionnaire developed by the international Union against Tuberculosis and Lung Disease (IUATLD) to assess bronchial symptoms has been tested for its ability to predict the bronchial response to histamine in adults adults aged 18-64 years living in two areas of southern England. A number of questions were found to be independently associated with increased reactivity in the first randomly selected half of the subjects. These symptoms included wheeze, waking at night with shortness of breath, tightness in the chest or shortness of breath when exposed to anaimals, dust or feathers and the non-specific symptom of persistent problems with breathing. A predictive score based on these symptoms was more sensitive and only slightly less specific than the question on wheeze alone in predicting the response to histamine in the second half of the subjects. Questions about asthma though more specific were considerably less sensitive than either. Symptoms did not differentiate between reactivity associated with positive skin tests and that associated with smoking.