Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells
Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells
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DOI：
10.1016/s0306-4522(03)00168-4
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Beck, H
中科院分区：
文献类型：
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作者：
Ellerkmann, RK;Remy, S;Beck, H
已知癫痫持续状态（S.E.）会导致电压依赖性离子通道和神经递质受体表达的大量变化。在本研究中，我们检查了 S.E. 的发作是否会导致 S.E.毛果芸香碱体内诱导改变了大鼠海马齿状颗粒细胞（DGC）中电压门控Na+通道的功能特性和表达。使用分离的DGC中的膜片钳记录，我们发现电压依赖性失活曲线在S.E.之后显着向去极化电位移动。与对照大鼠（-48.2+/-0.8 mV，P
Status epilepticus (S.E.) is known to lead to a large number of changes in the expression of voltage-dependent ion channels and neurotransmitter receptors. In the present study, we examined whether an episode of S.E. induced by pilocarpine in vivo alters functional properties and expression of voltage-gated Na+ channels in dentate granule cells (DGCs) of the rat hippocampus.Using patch-clamp recordings in isolated DGCs, we show that the voltage-dependent inactivation curve is significantly shifted toward depolarizing potentials following S.E. (half-maximal inactivation at -43.2+/-0.6 mV) when compared with control rats (-48.2+/-0.8 mV, P