Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Patients With Acute Respiratory Distress Syndrome
Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Patients With Acute Respiratory Distress Syndrome
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DOI：
10.1016/j.chest.2016.01.003
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发表时间：
2016-08-01
期刊：
影响因子：
9.6
通讯作者：
Brower, Roy G.
中科院分区：
文献类型：
--
作者：
Brown, Samuel M.;Grissom, Colin K.;Brower, Roy G.
背景：急性呼吸窘迫综合征（ARDS）是一个重要的临床问题。ARDS的定义需要检测动脉血气，以确定PaO 2与FIO 2的比值（PaO 2/FIO 2比值）。然而，许多患有ARDS的患者没有进行血气测量，这可能导致病情的诊断不足。因此，估计PaO 2的基础上，非侵入性measurements.METHODS：使用数据从三个ARDS网络研究，我们分析了登记动脉血气测量比较非线性与线性和对数线性插补方法估计PaO 2的血红蛋白与氧的饱和度百分比测量脉搏血氧饱和度（SpO（2））。为了确保临床等效性，我们根据不同的PaO 2/FIO 2比值测量值和估算值比较了死亡率。
BACKGROUND: ARDS is an important clinical problem. The definition of ARDS requires testing of arterial blood gas to define the ratio of PaO2 to FIO2 (PaO2/FIO2 ratio). However, many patients with ARDS do not undergo blood gas measurement, which may result in underdiagnosis of the condition. As a consequence, a method for estimating PaO2 on the basis of noninvasive measurements is desirable.METHODS: Using data from three ARDS Network studies, we analyzed the enrollment arterial blood gas measurements to compare nonlinear with linear and log-linear imputation methods of estimating PaO2 from percent saturation of hemoglobin with oxygen as measured by pulse oximetry (SpO(2)). We compared mortality on the basis of various measured and imputed PaO2/FIO2 ratio cutoffs to ensure clinical equivalence.RESULTS: We studied 1,184 patients, in 707 of whom the SpO(2)