Versatile and expeditious synthesis of aurones via AuI-catalyzed cyclization
Versatile and expeditious synthesis of aurones via AuI-catalyzed cyclization
复制标题
DOI：
10.1021/jo702197b
复制
发表时间：
2008-02-15
影响因子：
3.6
通讯作者：
Pale, Patrick
中科院分区：
文献类型：
--
作者：
Harkat, Hassina;Blanc, Aurelien;Pale, Patrick
橙酮可以方便地在三步程序中形成，包括金（I）催化的2-（1-羟基丙-2-炔基）苯酚环化作为高度区域和立体选择性的关键步骤。从取代的水杨醛开始可以获得多种多样的衍生物。合成了天然产物4，6，3 '，4'-四甲氧基橙酮，并对两个天然产物（dalmaisione D和4 '-氯橙酮）进行了结构修正。
[GRAPHICS]Aurones are conveniently formed in a three-step procedure including a gold(I)-catalyzed cyclization of 2-(1-hydroxyprop-2-ynyl)phenols as a highly regio- and stereoselective key step. A wide diversity of derivatives can be obtained starting from substituted salicylaldehydes. Synthesis of natural 4,6,3',4'-tetramethoxyaurone and structure revision of two natural products (dalmaisione D and 4'-chloroaurone) were achieved.