Modulation of a brain-behavior relationship in verbal working memory by rTMS
Modulation of a brain-behavior relationship in verbal working memory by rTMS
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DOI：
10.1016/s0926-6410(02)00196-9
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发表时间：
2003-02-01
期刊：
影响因子：
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通讯作者：
Krause, BJ
中科院分区：
文献类型：
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作者：
Mottaghy, FM;Pascual-Leone, A;Krause, BJ
我们研究了是否可以通过重复经颅磁刺激（rTMS）的左或右额中回（MFG）调制的正电子发射断层扫描（PET）测量的局部脑血流量（rCBF）和言语工作记忆（WM）的个人准确性之间的脑行为关系（BBR）。14名右利手男性受试者接受了30 s的rTMS列车（4 Hz，110%的运动阈值）的左或右MFG在2回WM任务使用字母作为刺激。同时注射rCBF PET示踪剂，获得全脑功能图像。进行了左和右MFG BBR的假设驱动的感兴趣区域分析以及将个体准确性与rCBF相关联的探索性全脑分析。在没有rTMS的情况下，我们发现左侧BBR为负，但右侧MFG中没有显着的BBR。这种负BBR最好的解释是一个更大的努力，志愿者与一个低劣的任务性能。左侧rTMS导致BBR向上级额回（SFG）移位，并在左侧SFG前部产生阳性BBR。右侧MFG的rTMS显示BBR位于左侧额下回的后下方。除了认知减法方法，这种相关性分析提供了关于前额叶皮层如何参与个人工作记忆表现的信息。结果进行了讨论沿着的想法，在一个活跃的神经元网络，反应到一个rTMS诱导的两个不同的网络模块的临时中断的短期可塑性。(C)2002 Elsevier Science B.V.保留所有权利。
We investigated whether the brain-behavior relationship (BBR) between regional cerebral blood flow (rCBF) as measured by positron emission tomography (PET) and individual accuracy in verbal working memory (WM) can be modulated by repetitive transcranial magnetic stimulation (rTMS) of the left or right middle frontal gyrus (MFG). Fourteen right-handed male subjects received a 30-s rTMS train (4 Hz, 110% motor threshold) to the left or right MFG during a 2-back WM task using letters as stimuli. Simultaneously an rCBF PET tracer was injected and whole-brain functional images were acquired. A hypothesis-driven region-of-interest-analysis of the left and right MFG BBR as well as an explorative whole-brain analysis correlating the individual accuracy with rCBF was carried out. Without rTMS we found a negative BBR in the left but no significant BBR in the right MFG. This negative BBR is best explained by an increased effort of volunteers with an inferior task performance. Left-sided rTMS led to a shift of the BBR towards the superior frontal gyrus (SFG) and to a positive BBR in anterior parts of the left SFG. With rTMS of the right MFG the BBR was posterior and inferior in the left inferior frontal gyrus. Beyond the cognitive subtraction approach this correlation analysis provides information on how the prefrontal cortex is involved based on individual performance in working memory. The results are discussed along the idea of a short-term plasticity in an active neuronal network that reacts to an rTMS-induced temporary disruption of two different network modules. (C) 2002 Elsevier Science B.V. All rights reserved.