Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance.
Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance.
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DOI：
10.3389/fimmu.2017.00403
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发表时间：
2017
影响因子：
7.3
通讯作者：
Ishimaru N
中科院分区：
文献类型：
--
作者：
Yamada A;Arakaki R;Saito M;Kudo Y;Ishimaru N
Fas介导的细胞凋亡有助于生理和病理细胞过程，如分化和存活。特别是，Fas在免疫细胞中的作用是复杂的，对于维持免疫耐受是至关重要的。免疫系统中与Fas/FasL介导的信号传导相关的精确途径和独特功能是已知的。Fas/FasL介导的免疫调节的双重特征，诱导有益或有害的影响与免疫疾病的发生或发展相关。对人和小鼠Fas和FasL基因突变的研究有助于我们对自身免疫性疾病发病机制的认识。本文就Fas/FasL介导的信号转导的相互作用、Fas/FasL在免疫细胞中的双向作用以及Fas/FasL介导的自身免疫的复杂发病机制作一综述。
Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. In particular, the roles of Fas in immune cells are complex and critical for the maintenance of immune tolerance. The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediated immune regulation that induces beneficial or harmful effects is associated with the onset or development of immune disorders. Studies on mutations in genes encoding Fas and FasL gene of humans and mice contributed to our understanding of the pathogenesis of autoimmune diseases. Here, we review the opposing functions of Fas/FasL-mediated signaling, bilateral effects of Fas/FasL on in immune cells, and complex pathogenesis of autoimmunity mediated by Fas/FasL.