ENHANCEMENT OF TUMORIGENESIS BY N-NITROSODIETHYLAMINE, N-NITROSOPYRROLIDINE AND N6(METHYLNITROSO)-ADENOSINE BY ETHANOL
ENHANCEMENT OF TUMORIGENESIS BY N-NITROSODIETHYLAMINE, N-NITROSOPYRROLIDINE AND N6(METHYLNITROSO)-ADENOSINE BY ETHANOL
复制标题
DOI：
10.1016/0304-3835(93)90220-4
复制
发表时间：
1993-01-15
期刊：
影响因子：
9.7
通讯作者：
GINERSOROLLA, A
中科院分区：
文献类型：
--
作者：
ANDERSON, LM;CARTER, JP;GINERSOROLLA, A
与单独致癌物相比，在A系雄性小鼠的饮用水中加入10%乙醇和6.8 ppm N-亚硝基二乙胺导致肺肿瘤的多样性增加4倍，前胃肿瘤的发病率增加16倍。给予40 ppm N-亚硝基吡咯烷，乙醇导致肺肿瘤多样性增加5.5倍。瑞士雌性小鼠经口给予含有N6（甲基亚硝基）腺苷的15%乙醇，导致体重减轻和与血管肉瘤发生相关的生存时间缩短或胸腺淋巴瘤发生率增加，这取决于致癌物的剂量。这些数据提供了额外的支持的建议，共同管理的乙醇增加亚硝胺的致瘤性阻断肝脏首过清除。
Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5.5-fold increase in lung tumor multiplicity. The inclusion of 15 % ethanol with N6 (methylnitroso)adenosine, given orally to Swiss female mice, led to reduced body weights and shortened survival time related to hemangiosarcoma occurrence or increased incidence of thymic lymphoma, depending on dose of carcinogen. The data provide additional support for the proposal that co-administered ethanol increases the tumorigenicity of nitrosamines by blocking hepatic first-pass clearance.