Extracellular glutamate: functional compartments operate in different concentration ranges.
Extracellular glutamate: functional compartments operate in different concentration ranges.
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DOI：
10.3389/fnsys.2011.00094
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发表时间：
2011
影响因子：
3
通讯作者：
Kalivas PW
中科院分区：
文献类型：
--
作者：
Moussawi K;Riegel A;Nair S;Kalivas PW
神经胶质源的细胞外谷氨酸调节神经胶质和神经元谷氨酸的释放和突触可塑性。细胞外谷氨酸盐的基础浓度估计值超过三个数量级（0.02-20 μM），具体取决于测量所采用的技术。基于谷氨酸受体和转运蛋白的结合常数，该浓度范围转化为细胞外谷氨酸的不同生理和病理生理作用。在这里，我们推测，在谷氨酸测量的差异可以解释，如果有模式的膜表面表达谷氨酸释放和转运网站创建细胞外亚室，不同的谷氨酸浓度和优先采样不同的技术。
Extracellular glutamate of glial origin modulates glial and neuronal glutamate release and synaptic plasticity. Estimates of the tonic basal concentration of extracellular glutamate range over three orders of magnitude (0.02–20 μM) depending on the technology employed to make the measurement. Based upon binding constants for glutamate receptors and transporters, this range of concentrations translates into distinct physiological and pathophysiological roles for extracellular glutamate. Here we speculate that the difference in glutamate measurements can be explained if there is patterned membrane surface expression of glutamate release and transporter sites creating extracellular subcompartments that vary in glutamate concentration and are preferentially sampled by different technologies.