Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease
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DOI：
10.1161/01.cir.0000074207.85796.36
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发表时间：
2003-07-01
期刊：
影响因子：
37.8
通讯作者：
Kamboh, MI
中科院分区：
文献类型：
--
作者：
Chen, Q;Reis, SE;Kamboh, MI
背景 - 我们在女性缺血综合征评估 (WISE) 研究人群中检查了凝集素样氧化 LDL 受体 1（LOX1 或 OLR1）基因中的 3 个多态性与冠状动脉疾病的关联。方法和结果 - WISE 样本包括 589 名白人和 122 名黑人女性，她们因疑似缺血而接受了血管造影。样本分为 3 组： = 50% 狭窄 (35.3%)。三个LOX1多态性（内含子4/G-->A、内含子5/T-->G和3'UTR/T-->C）处于连锁不平衡状态，因此表现为单一多态性。白人中 3' UTR/T 等位基因的频率显着高于黑人（49% 对比 19%；P
Background-We examined the association of 3 polymorphisms in the lectin-like oxidized LDL receptor-1 (LOX1 or OLR1) gene with coronary artery disease in the Women's Ischemia Syndrome Evaluation (WISE) study population.Methods and Results-The WISE sample comprised 589 white and 122 black women who underwent angiography for suspected ischemia. The sample was divided into 3 groups: = 50% stenosis (35.3%). The three LOX1 polymorphisms (intron 4/G-->A, intron 5/T-->G, and 3' UTR/T-->C) were in linkage disequilibrium and thus behaved as a single polymorphism. The frequency of the 3' UTR/T allele was significantly higher in whites than blacks (49% versus 19%; P