ULTRASTRUCTURAL FEATURES OF HOST-PARASITE RELATIONSHIP IN ORAL CANDIDIASIS
ULTRASTRUCTURAL FEATURES OF HOST-PARASITE RELATIONSHIP IN ORAL CANDIDIASIS
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DOI：
10.1128/jb.96.4.1349-1356.1968
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发表时间：
1968-01-01
影响因子：
3.2
通讯作者：
WILBORN, WH
中科院分区：
文献类型：
--
作者：
MONTES, LF;WILBORN, WH
在口腔念珠菌病中，许多角化上皮细胞和白色念珠菌细胞脱落。用口腔念珠菌病患者的鳞片电镜观察上皮与真菌的关系。从舌头和口腔黏膜刮下鳞片，固定真菌。电镜观察显示c细胞。白色念珠菌在上皮细胞外、穿透或在上皮细胞内。细胞外真菌具有附着在细胞壁外表面的絮状物质。细胞内真菌缺乏絮状物质，当真菌侵入上皮细胞时，絮状物质似乎会脱落。真菌细胞的细胞质中有大液泡，有时含有髓鞘图。上皮细胞常含有几种真菌。不连续的质膜标记了真菌进入的位置。没有真菌的细胞质区域显示出许多张力原纤维，但邻近真菌的细胞质通常缺乏张力原纤维。显微照片显示真菌细胞溶解了张力原纤维。细菌在刮擦物中丰富，但总是占据细胞外的位置。
In oral candidiasis, many keratinized epithelial cells and cells ofCandida albicansare shed. Scales from patients with oral candidiasis were used for electron microscopic study of the epithelial-fungal relationship. Scales, scraped from the tongue and oral mucosa, were fixed for fungi. Electron microscopic observations showed cells ofC. albicansoutside, penetrating, or within the epithelial cells. Extracellular fungi possessed a floccular material adherent to the outer surface of the cell wall. Intracellular fungi lacked the floccular material which appeared to detach as fungi invaded the epithelial cells. Large vacuoles, which sometimes contained myelin figures, occupied the cytoplasm of fungal cells. Epithelial cells frequently contained several fungi. Discontinuous plasma membranes marked sites of fungal entry. Cytoplasmic areas devoid of fungi showed many tonofibrils, but the cytoplasm adjacent to fungi often lacked tonofibrils. Micrographs suggested that fungal cells lysed the tonofibrils. Bacteria were abundant in the scrapings, but always occupied an extracellular position.