Height and body mass index in relation to esophageal cancer; 23-year follow-up of two million Norwegian men and women
Height and body mass index in relation to esophageal cancer; 23-year follow-up of two million Norwegian men and women
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DOI：
10.1023/b:caco.0000043434.21558.ea
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发表时间：
2004-10-01
影响因子：
2.3
通讯作者：
Bjorge, T
中科院分区：
文献类型：
--
作者：
Engeland, A;Tretli, S;Bjorge, T
目的：大量研究探讨了体重指数（BMI）、身高与不同部位癌症之间的关系。对于食管癌，BMI对于不同的组织学亚型似乎有不同的影响。我们在挪威队列中探索了这些关系。材料和方法：1963年至2001年期间测量了200万挪威人的身高和体重。在随访期间，登记了2245例经组织学证实的食管癌病例。采用比例考克斯回归分析方法估计食管癌的相对危险度（RR）。在体重指数为18.5 - 24.9 kg/m2的超重男性中，（BMI 25 - 29 kg/m2）：RR = 1.80（95% CI：1.48 - 2.19），肥胖男性（BMI ≥ 30 kg/m2）：RR = 2.58（95% CI：1.81 - 3.68）。女性的相应风险估计值为RR = 1.64（95%CI：1.08 - 2.49）和RR = 2.06（95%CI：1.25 - 3.39）。食管鳞状细胞癌（OSCC）则相反。对于超重男性，OSCC的RR为0.72（95%CI：0.63 - 0.82），肥胖男性为0.68（95%CI：0.50 - 0.93）。女性的相应RR估计值为0.52（95% CI：0.42 - 0.65）和0.43（95% CI：0.32 - 0.59）。此外，一般来说，最低的男性患食道癌的风险最高。结论：BMI与食管癌两种最常见的组织学类型呈相反的关系。虽然低BMI增加了OSCC的风险，但高BMI增加了OA的风险。在最低的男性中发现食管癌的风险增加。
Objective: Associations between body mass index (BMI) and stature and cancers at different sites have been explored in a number of studies. For esophageal cancer there seems to be different effects of BMI for different histological subtypes. We explored these relations in a Norwegian cohort.Material and methods: Height and weight were measured in 2 million Norwegians during 1963 - 2001. During follow-up, 2245 histologically verified esophageal cancer cases were registered. Relative risks (RR) of esophageal cancer were estimated using proportional Cox regression.Results: Compared with normal weighted (BMI 18.5 - 24.9 kg/m(2)) an increased risk of esophageal adenocarcinoma (OA) was observed in overweight men (BMI 25 - 29 kg/m(2)): RR = 1.80 (95% CI: 1.48 - 2.19) and in obese men ( BMI greater than or equal to 30 kg/m(2)): RR = 2.58 (95% CI: 1.81 - 3.68). The corresponding risk estimates for women were RR = 1.64 ( 95% CI: 1.08 - 2.49) and RR = 2.06 ( 95% CI: 1.25 - 3.39). The opposite relation was observed for esophageal squamous cell carcinoma (OSCC). For overweight men the RR of OSCC was 0.72 ( 95% CI: 0.63 - 0.82) and 0.68 ( 95% CI: 0.50 - 0.93) for obese. The corresponding RR estimates for women were 0.52 ( 95% CI: 0.42 - 0.65) and 0.43 ( 95% CI: 0.32 - 0.59). In addition, the lowest men had the highest risk of esophageal cancer in general. Adjustment for smoking did not change these relations.Conclusion: BMI had opposite relations to the two most common histological groups of esophageal cancer. While low BMI increased the risk of OSCC, high BMI increased the risk of OA. An increased risk of esophageal cancer was found in the lowest men.