Encapsulation by interfacial polycondensation. II. The membrane wall structure and the rate of the wall growth
Encapsulation by interfacial polycondensation. II. The membrane wall structure and the rate of the wall growth
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DOI：
10.1016/0376-7388(92)87054-2
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发表时间：
1992
影响因子：
9.5
通讯作者：
Leon M. Janssen;K. Nijenhuis
中科院分区：
文献类型：
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作者：
Leon M. Janssen;K. Nijenhuis
研究了对苯二甲酰氯(TDC)和二乙烯三胺(DETA)的界面缩聚法包封邻苯二甲酸二丁酯。胶囊壁的生长速率由 DETA 穿过壁扩散到油相中来确定。由于 TDC 与 DETA 发生反应，胶囊内 TDC 的浓度降低。 TDC浓度的降低和壁厚的增长均与√t呈线性关系。这验证了壁厚和TDC浓度之间的模型关系。壁生长速率是膜的聚合物特性的函数。 TDC 和 DETA 在油相和水相中的浓度比分别决定了聚合物的性质，从而决定了胶囊壁的生长速率。封装的 TDC 水解速率的测量表明，在壁形成过程中不会发生水解，因为水解仅发生在水相中。
The encapsulation of dibutylphthalate by interfacial polycondensation of terephthaloyldichloride (TDC) and diethylenetriamine (DETA) was studied. The growth rate of the capsule wall is determined by diffusion of DETA through the wall into the oil phase. Due to the reaction of TDC with DETA the concentration of TDC inside the capsules decreases. Both the concentration decrease of TDC and the growth of the wall thickness are linear with √t. This verifies the model relations between the wall thickness and the TDC concentration. The rate of wall growth is a function of the polymer properties of the membrane. The concentration ratio of TDC and DETA in the oil and aqueous phase, respectively, determines the polymer properties and consequently, also the growth rate of the capsule wall. Mesurements of the rate of hydrolysis of encapsulated TDC show that no hydrolysis will take place during wall formation, as hydrolysis only takes place in the aqueous phase.