Optically Transparent, Amphiphilic Networks Based on Blends of Perfluoropolyethers and Poly(ethylene glycol)
Optically Transparent, Amphiphilic Networks Based on Blends of Perfluoropolyethers and Poly(ethylene glycol)
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DOI：
10.1021/ja803991n
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发表时间：
2008-10-29
影响因子：
15
通讯作者：
DeSimone, Joseph M.
中科院分区：
文献类型：
--
作者：
Hu, Zhaokang;Chen, Liang;DeSimone, Joseph M.
全氟聚醚的两亲网络； (PFPE) 和聚乙二醇 (PEG) 已被用来生产各种成分的光学透明、机械坚固的薄膜。这些低聚物的遥爪二醇被转化为可光固化的二甲基丙烯酰氧基形式(DMA)，并以不同的组合物重量进行自由基固化。产生独立薄膜的比率。当使用低摩尔质量版本的 PFPE-DMA (1 kg/mol) 和 PEG-DMA (550 g/mol) 时，可以获得透明无色的两亲网络。样品的整体形貌通过紫外可见光谱、差示扫描量热法、动态机械热分析、小角 X 射线散射、原子力显微镜、X 射线光电子能谱和光学显微镜等多种技术进行了广泛的表征，这强烈表明纳米级到宏观的相分离材料可以被表征。 实现了。通过将一定量的 PFPE 纳入基于 PEG 的水凝胶网络中，可以显着减少水膨胀，这可能为许多医疗设备应用提供新策略。沿着这些思路，与基于寡聚乙二醇的自组装单层涂层表面相比，这些两亲性网络材料可以实现对非特异性蛋白质吸附的强烈抑制。
Amphiphilic networks of perfluoropolyethers; (PFPE) and poly(ethylene glycol) (PEG) have been achieved to yield optically transparent, mechanically robust films over a wide range of compositions. Telechelic diols of these oligomers were transformed to a photocurable dimethacryloxy form (DMA) and free radically cured at various composition weight. ratios to yield free-standing films. Clear and colorless amphiphilic networks could be achieved when low molar mass versions of both the PFPE-DMA (1 kg/mol) and the PEG-DMA (550 g/mol) were used. The bulk morphologies of the samples were extensively characterized by a variety of techniques including ultraviolet-visible spectroscopy, differential scanning calorimetry, dynamic mechanic thermal analysis, small-angle X-ray scattering, atomic force microscopy, X-ray photoelectron spectroscopy, and optical microscopy, which strongly suggest that nanoscopic to macroscopic phase-separated materials could be achieved. By incorporating a threshold amount of PFPEs into PEG-based hydrogel networks, water swelling could be significantly reduced, which may offer a new strategy for a number of medical device applications. Along these lines, strong inhibition of nonspecific protein adsorption could be achieved with these amphiphilic network materials compared with an oligo(ethylene glycol)-based self-assembled monolayer coated surface.