The influence of initial target effect-site concentrations of propofol on the similarity of effect-sites concentrations at loss and return of consciousness in elderly female patients with the Diprifusor system.
The influence of initial target effect-site concentrations of propofol on the similarity of effect-sites concentrations at loss and return of consciousness in elderly female patients with the Diprifusor system.
复制标题
丙泊酚的初始靶效应位点浓度对二倍体系统老年女性患者丧失和意识回报时的效应浓度相似性的影响。
DOI：
10.4103/0970-9185.94851
复制
发表时间：
2012-04
期刊：
影响因子：
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通讯作者：
Mashimo T
中科院分区：
文献类型：
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作者：
Shibuta S;Kanemura S;Uchida O;Mashimo T
使用Diprifusor的老年妇女意识丧失和意识恢复（LOC和ROC分别）时异丙酚（Cep）的效应位点浓度是否相似尚不清楚。我们研究了初始目标Cep （Ctarget）的差异是否会改变LOC和ROC Cep值之间的相似性。在本研究中，接受膝关节置换术的女性患者（n = 58，年龄= 72.5±1.1岁）给予异丙酚和Diprifusor。测定不同Ctarget值（3.0 ~ 4.5 μg/ml）时LOC和ROC的Cep值。采用Pearson相关系数分析和简单回归评估各Ctarget的LOC Cep与ROC的关系。各目标组回归线相关系数的差异采用t检验。不同的Ctarget组在LOC或ROC的总异丙酚水平和Cep值上没有显着差异。然而，当Ctarget为4.0和4.5 μg/ml时，ROC时的Cep值显著高于LOC时的Cep值，而低Ctarget组的Cep值无显著差异。所有c靶组LOC时的Cep与ROC之间均存在显著正相关。不同目标组的回归系数无显著差异。与低Ctarget（≤3.5 μg/ml）组相比，高Ctarget组的LOC时间明显缩短。诱导质量各组间无显著差异。在老年妇女中，当Ctarget为3.0-4.5 μg/ml时，LOC Cep值是ROC Cep的有力预测指标。高靶组（≥4.0 μg/ml）诱导时间短，心血管稳定性正常。
Whether effect-site concentrations of propofol (Cep) at loss of consciousness and return of consciousness (LOC and ROC, respectively) in elderly women using Diprifusor are similar is unclear. We investigated whether differences in initial target Cep (Ctarget) alter similarities between Cep values at LOC and ROC. In this study, female patients (n = 58, age = 72.5 ± 1.1 years) undergoing knee arthroplasty were administered propofol with Diprifusor. Cep at LOC and ROC were estimated for different Ctarget values (3.0–4.5 μg/ml). Pearson's correlation coefficient analysis and simple regression were performed to assess the relationship between Cep at LOC and ROC for each Ctarget. Differences in correlation coefficients of regression lines obtained from each Ctarget group were determined using the t-test. The different Ctarget groups did not show significant differences in total propofol levels and in Cep values at LOC or ROC. However, Cep at ROC was significantly higher than Cep at LOC when Ctarget was 4.0 and 4.5 μg/ml, whereas these Cep values were not significantly different in low Ctarget groups. Strong positive correlations were observed between Cep at LOC and ROC for all Ctarget groups. Regression coefficients for the different Ctarget groups were not significantly different. Compared to low (≤3.5 μg/ml) Ctarget groups, high Ctarget groups showed significantly shorter time until LOC. Induction quality was not significantly different among the groups. In elderly women, Cep values at LOC are strong predictors of Cep at ROC when Ctarget is 3.0–4.5 μg/ml. High Ctarget groups (≥4.0 μg/ml) exhibited shorter induction times with normal cardiovascular stability.