MR connectomics: a conceptual framework for studying the developing brain.
MR connectomics: a conceptual framework for studying the developing brain.
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DOI：
10.3389/fnsys.2012.00043
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发表时间：
2012
影响因子：
3
通讯作者：
Fair DA
中科院分区：
文献类型：
--
作者：
Hagmann P;Grant PE;Fair DA
先进的神经成像技术和复杂网络科学的重大发展相结合，产生了一个研究大脑的新框架：“连接组学”。这个框架提供了描述和研究大脑作为一个动态网络的能力，并探索如何协调和整合信息处理可能发生。近年来，这一框架已被用于研究发育中的大脑，并揭示了从婴儿期到成年期发生的许多动态变化。本文的目的是回顾这项工作，并讨论我们从中学到了什么。我们还将利用这项工作来强调使用当今先进的神经影像技术进行成功的连接体分析所必需的关键技术方面。我们希望确定目前的局限性，这些方法，可以改进，以及如何将这些点推广到连接体研究的其他主题。
The combination of advanced neuroimaging techniques and major developments in complex network science, have given birth to a new framework for studying the brain: “connectomics.” This framework provides the ability to describe and study the brain as a dynamic network and to explore how the coordination and integration of information processing may occur. In recent years this framework has been used to investigate the developing brain and has shed light on many dynamic changes occurring from infancy through adulthood. The aim of this article is to review this work and to discuss what we have learned from it. We will also use this body of work to highlight key technical aspects that are necessary in general for successful connectome analysis using today's advanced neuroimaging techniques. We look to identify current limitations of such approaches, what can be improved, and how these points generalize to other topics in connectome research.