Self-reported arm and shoulder problems in breast cancer survivors in Sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort study.
Self-reported arm and shoulder problems in breast cancer survivors in Sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort study.
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DOI：
10.1186/s13058-021-01486-9
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发表时间：
2021-11-24
期刊：
影响因子：
--
通讯作者：
McCormack V
中科院分区：
文献类型：
--
作者：
Boucheron P;Anele A;Zietsman A;Galukande M;Parham G;Pinder LF;Andersson TM;Anderson BO;Foerster M;Schüz J;Dos Santos Silva I;McCormack V
在前哨淋巴结活检成为护理标准之前，包括淋巴水肿在内的手臂和肩部问题(ASP)在高收入国家的乳腺癌女性中很常见。尽管ASP影响日常生活活动，从而损害生活质量，但它们在撒哈拉以南非洲的频率和决定因素仍不清楚。所有在非洲乳腺癌-预后差异(ABC-DO)队列研究的纳米比亚、乌干达、尼日利亚和赞比亚站点新诊断为乳腺癌的女性都被包括在内。在每次为期3个月的跟踪采访中，女性回答了EORTC-QLQ-Br23问卷，包括三个ASP项目：肩臂疼痛、手臂僵硬和手臂/手肿胀。我们估计了第一次自我报告的ASP的累积发生率，总体上，并按研究和治疗状态分层，死亡被视为相互竞争的事件。为了确定ASP的决定因素，我们使用COX模型对研究地点进行分层，估计了特定原因的风险比。在1476名妇女中，在确诊后4年内，43%(95%可信区间40-46)、36%(33-38)和23%(20-25)分别自我报告至少经历过一次手臂/肩部疼痛、僵硬和手臂/手肿胀。尽管不同地点自我报告的ASP的风险不同，但诊断时乳腺癌的晚期、社会经济地位较低和接受治疗会增加报告ASP的风险。在撒哈拉以南非洲的乳腺癌幸存者中，ASP非常常见。它们受到不同于高收入国家观察到的因素的影响。有必要在非洲背景下提高对ASP的认识并改进管理。网上版载有补充材料，可在10.1186/s13058021-01486-9查阅。
Arm and shoulder problems (ASP), including lymphedema, were common among women with breast cancer in high-income countries before sentinel lymph node biopsy became the standard of care. Although ASP impair quality of life, as they affect daily life activities, their frequency and determinants in Sub-Saharan Africa remain unclear. All women newly diagnosed with breast cancer at the Namibian, Ugandan, Nigerian, and Zambian sites of the African Breast Cancer-Disparities in Outcomes (ABC-DO) cohort study were included. At each 3-month follow-up interview, women answered the EORTC-QLQ-Br23 questionnaire, including three ASP items: shoulder/arm pain, arm stiffness, and arm/hand swelling. We estimated the cumulative incidence of first self-reported ASP, overall and stratified by study and treatment status, with deaths treated as competing events. To identify determinants of ASP, we estimated cause-specific hazard ratios using Cox models stratified by study site. Among 1476 women, up to 4 years after diagnosis, 43% (95% CI 40–46), 36% (33–38) and 23% (20–25), respectively, self-reported having experienced arm/shoulder pain, stiffness and arm/hand swelling at least once. Although risks of self-reported ASP differed between sites, a more advanced breast cancer stage at diagnosis, having a lower socioeconomic position and receiving treatment increased the risk of reporting an ASP. ASP are very common in breast cancer survivors in Sub-Saharan Africa. They are influenced by different factors than those observed in high-income countries. There is a need to raise awareness and improve management of ASP within the African setting. The online version contains supplementary material available at 10.1186/s13058-021-01486-9.
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影响因子：
5
作者：
Foerster, Milena;Anele, Angelica;McCormack, Valerie
通讯作者：
McCormack, Valerie
影响因子：
51.1
作者：
Krag, David N.;Anderson, Stewart J.;Julian, Thomas B.;Brown, Ann M.;Harlow, Seth P.;Costantino, Joseph P.;Ashikaga, Takamaru;Weaver, Donald L.;Mamounas, Eleftherios P.;Jalovec, Lynne M.;Frazier, Thomas G.;Noyes, R. Dirk;Robidoux, Andre;Scarth, Hugh M. C.;Wolmark, Norman
通讯作者：
Wolmark, Norman
DOI：
10.1016/j.breast.2013.07.050
发表时间：
2013-10
期刊：
Breast (Edinburgh, Scotland)
影响因子：
--
作者：
Cardoso F;Bese N;Distelhorst SR;Bevilacqua JL;Ginsburg O;Grunberg SM;Gralla RJ;Steyn A;Pagani O;Partridge AH;Knaul FM;Aapro MS;Andersen BL;Thompson B;Gralow JR;Anderson BO
通讯作者：
Anderson BO
影响因子：
3.8
作者：
Shamley, Delva;Srinaganathan, Ragavan;Sugden, Elaine
通讯作者：
Sugden, Elaine
影响因子：
2.3
作者：
McKenzie, Fiona;Zietsman, Annelle;McCormack, Valerie
通讯作者：
McCormack, Valerie