The relative importance of socio-economic status, parental smoking and air pollution (SO2) on asthma symptoms, spirometry and bronchodilator response in 11-year-old children
The relative importance of socio-economic status, parental smoking and air pollution (SO2) on asthma symptoms, spirometry and bronchodilator response in 11-year-old children
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DOI：
10.1034/j.1399-3038.1999.00024.x
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发表时间：
1999-05-01
影响因子：
4.4
通讯作者：
Barbero, P
中科院分区：
文献类型：
--
作者：
García-Marcos, L;Guillén, JJ;Barbero, P
本研究的目的是评估几种危险因素对过敏性呼吸道症状患病率的相对影响，以及非诺特罗支气管扩张剂试验的阳性率，并确定这些因素对 FVC、FEV1、PEF、MEF25、MEF50 和 MEF75 变异性的相对重要性。研究对象为西班牙卡塔赫纳市污染区和非污染区的 340 名 11 岁儿童。近10年污染区年均SO2浓度为75μg/m(3)，未污染区同期<20μg/m(3)。父母完成了一份有关过敏性呼吸道症状的调查问卷。其中包括有关父母吸烟习惯和社会经济水平的具体问题。评估每个儿童在吸入 0.2 毫克非诺特罗之前和之后的肺活量测定表现。逻辑回归中唯一显着的预测变量（对于患有任何症状或支气管扩张剂阳性反应）是鼻部症状的男性（RR 1.37；p = 0.04）和眼部症状的住房靠近交通繁忙的地方（RR 1.45；p = 0.01）。生活在污染地区可降低支气管扩张剂阳性反应的风险（RR 0.61；p = 0.004）。母亲吸烟，尽管在统计上不显着，但往往会增加出现任何症状的风险（RR 1.26；p = 0.07）或出现支气管扩张剂阳性反应（RR 1.23；p = 0.1）。研究的所有风险因素对于解释肺活量测定结果的变异性都没有显着的重要性。尽管没有任何危险因素对症状问题、支气管扩张剂测试或肺活量测量有具体决定作用，但如果考虑到统计上不显着的趋势，那么母亲吸烟似乎比生活在污染地区更重要。
The aim of this study was to evaluate the relative contribution of several risk factors to the prevalence of allergic respiratory symptoms, and the positivity of the bronchodilator test with fenoterol, and to establish the relative importance of these factors on the variability of FVC, FEV1, PEF, MEF25, MEF50 and MEF75. A total of 340 11-year-old children attending school in polluted and non-polluted areas of the city of Cartagena, Spain, were studied. The polluted area had had an annual mean of 75 mu g/m(3) of SO2 over the last 10 years and the non-polluted area had < 20 mu g/m(3) during this period. A questionnaire about allergic respiratory symptoms was completed by the parents. Specific questions about parental smoking habits and socio-economic level were included. Each child's performance in spirometry before and after administration of 0.2 mg of inhaled fenoterol was evaluated. The only significant predictive variables in the logistic regression (for suffering any symptom or a positive bronchodilator response) were male sex for nasal symptoms (RR 1.37; p = 0.04) and housing near heavy traffic for eye symptoms (RR 1.45; p = 0.01). Living in the polluted area reduced the risk of a positive bronchodilator response (RR 0.61; p = 0.004). Maternal smoking, even though not statistically significant, tended to increased the risk of suffering any symptom (RR 1.26; p = 0.07) or of having a positive bronchodilator response (RR 1.23; p = 0.1). None of the risk factors studied was of significant importance in explaining the variability of spirometry results. Although none of the risk factors were specifically determinant to the symptom questions, bronchodilator test or spirometric measurements, having a mother who smokes seems more important than living in a polluted area if statistically non-significant trends are considered.