JUNCTIONS BETWEEN CANCER CELLS IN CULTURE - ULTRASTRUCTURE AND PERMEABILITY
JUNCTIONS BETWEEN CANCER CELLS IN CULTURE - ULTRASTRUCTURE AND PERMEABILITY
复制标题
DOI：
10.1126/science.174.4010.717
复制
发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
SHERIAN, JD
中科院分区：
文献类型：
--
作者：
JOHNSON, RG;SHERIAN, JD
用超微结构、电生理和染料注射技术研究了在悬浮培养中以小块或链状生长的Novikoff肝癌细胞(N1S1-67)之间的细胞连接。团块内的细胞通常是电偶联的，可以交换分子量在332到500之间的染料。缝隙连接和中间连接存在，而真正的紧密连接和桥粒则不存在或非常罕见。该系统将为研究“通信”结的性质提供一个有用的模型。
Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions.