Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites
Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites
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DOI：
10.1093/ajcn/67.2.342
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发表时间：
1998-02-01
影响因子：
7.1
通讯作者：
Balhorn, KE
中科院分区：
文献类型：
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作者：
Kinyamu, HK;Gallagher, JC;Balhorn, KE
在这项研究中，测量了 376 名 65-77 岁自由生活女性的血清钙和维生素 D 对血清甲状旁腺激素和维生素 D 代谢物的影响。两组的平均钙摄入量接近推荐的膳食摄入量 800 毫克/天。 245 名未服用维生素 D 补充剂的女性的平均维生素 D 摄入量为 3.53 微克/天（141 IU/天），低于推荐膳食摄入量 5 微克/天（200 IU/天）。为了检验维生素 D 在降低血清甲状旁腺激素方面比钙更重要的假设，膳食钙摄入来源被细分为添加了维生素 D 的牛奶和非牛奶来源。血清甲状旁腺激素浓度与牛奶中的钙摄入量呈负相关（r = -0.20，P < 0.01），但与非牛奶来源的钙摄入量无关（r = -0.06）。此外，血清骨化二醇与牛奶钙摄入量相关（r = 0.35，P < 0.001），但与非牛奶钙摄入量无关（r = 0.10）。多变量分析显示季节对血清骨化二醇有显着影响，但对血清甲状旁腺激素没有显着影响。血清甲状旁腺激素与血清骨化二醇呈负相关（r = -0.33，P < 0.001），回归预测，当血清骨化二醇为122 nmol/L（49 ng/mL）时，老年人的平均血清甲状旁腺激素将降低至年轻人的正常浓度；这将需要比 5 微克/天（200 IU/天）更高的维生素 D 推荐膳食摄入量。
In this study, the effect of dietary calcium and vitamin D on serum parathyroid hormone and vitamin D metabolites was measured in 376 free-living women aged 65-77 y. Mean calcium intake in both groups was close to the recommended dietary allowance of 800 mg/d. Mean vitamin D intake in the 245 women not taking vitamin D supplements was 3.53 mu g/d (141 IU/d), which is below the recommended dietary allowance of 5 mu g/d (200 IU/d), To test the hypothesis that vitamin D is more important than calcium in reducing serum parathyroid hormone, the source of dietary calcium intake was subdivided into milk, which is fortified with vitamin D. and nonmilk sources. The serum parathyroid hormone concentration was inversely correlated with calcium intake derived from milk (r = -0.20, P < 0.01)but not from nonmilk sources (r = -0.06). Furthermore, serum calcidiol correlated with milk calcium intake (r = 0.35, P < 0.001) but not with nonmilk calcium intake (r = 0.10). Multivariate analysis showed a significant effect of season on serum calcidiol but not on serum parathyroid hormone. Serum parathyroid hormone was inversely correlated with serum calcidiol (r = -0.33, P < 0.001) and the regression predicted that mean serum parathyroid hormone would be reduced in the elderly to concentrations considered normal in the young when serum calcidiol is 122 nmol/L (49 ng/mL); this would require a much higher recommended dietary allowance for vitamin D than 5 mu g/d (200 IU/d).