Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.
Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.
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DOI：
10.1021/acs.orglett.5b01328
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发表时间：
2015-06-19
期刊：
影响因子：
5.2
通讯作者：
MacMillan JB
中科院分区：
文献类型：
--
作者：
Fu P;MacMillan JB
Spithioneines A 和 B（1 和 2）是两种新的波西米明型吡咯里西啶生物碱，具有不寻常的麦角硫因部分，是从海洋来源的 Streptomyces spinoverrucosus 中分离出来的。通过光谱分析、圆二色光谱、化学降解和合成阐明了它们的结构。化合物 1 和 2 是罕见的含有氨基酸麦角硫因的天然产物。
Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.