Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site.
Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site.
复制标题
大肠杆菌蛋白YBGI的晶体结构，一种带有双核金属位点的环形结构。
DOI：
10.1186/1472-6807-3-7
复制
发表时间：
2003-09-30
影响因子：
--
通讯作者：
Gilliland, Gary L
中科院分区：
文献类型：
--
作者：
Ladner, Jane E;Obmolova, Galina;Teplyakov, Alexey;Howard, Andrew J;Khil, Pavel P;Camerini-Otero, R Daniel;Gilliland, Gary L
基因 ybgI 编码的蛋白质被选为结构基因组学项目的目标，该项目强调蛋白质结构与功能的关系。 ybgI蛋白的结构是由六条多肽链组成的环形，形成二聚体的三聚体。每条多肽链在环形线圈的内侧结合两个金属离子。环形结构与一些参与 DNA 代谢的蛋白质的结构相当。双核金属位点可能意味着该蛋白质的特定功能是作为水解酶-氧化酶。
The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function. The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid. The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.