Eosinophilic Lung Diseases
Eosinophilic Lung Diseases
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DOI：
10.1016/j.iac.2012.08.007
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发表时间：
2012-11-01
影响因子：
2.6
通讯作者：
Cordier, Jean-Francois
中科院分区：
文献类型：
--
作者：
Cottin, Vincent;Cordier, Jean-Francois
嗜酸性粒细胞性肺病包括嗜酸性粒细胞性肺炎，可表现为慢性或急性发作，或表现为Loffler综合征。嗜酸性粒细胞性肺炎的诊断依赖于临床影像学和肺泡嗜酸性粒细胞增多的表现。肺活检通常是不必要的。外周血嗜酸性粒细胞增多在特发性急性嗜酸性粒细胞性肺炎中很常见，但在临床上可能不存在，这可能会被误诊为严重的感染性肺炎。胸外表现应怀疑Churg-Strauss综合征。在诊断特发性疾病之前，必须彻底调查嗜酸性粒细胞增多症的所有可能原因（特别是真菌感染或药物或有毒物质暴露）。
Eosinophilic lung diseases comprise eosinophilic pneumonia, which may present with chronic or acute onset, or as Loffler syndrome. The diagnosis of eosinophilic pneumonia relies on clinical imaging and the demonstration of alveolar eosinophilia. Lung biopsy is generally not necessary. Peripheral blood eosinophilia is common but may be absent at presentation in idiopathic acute eosinophilic pneumonia, which may be misdiagnosed as severe infectious pneumonia. Extra-thoracic manifestations should raise the suspicion of Churg-Strauss syndrome. All possible causes of eosinophilia (especially fungus infection or drug or toxic exposure) must be thoroughly investigated before the diagnosis of idiopathic disease is made.