Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis
Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis
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DOI：
10.1016/j.ympev.2009.02.023
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发表时间：
2009-06-01
影响因子：
4.1
通讯作者：
Saitou, Naruya
中科院分区：
文献类型：
--
作者：
Kitano, Takashi;Noda, Reiko;Saitou, Naruya
灵长类 ABO 血型基因编码糖基转移酶（A 型或 B 型），已知人类等位基因谱系之间的合并时间较长。我们确定了大约的核苷酸序列。对三个长臂猿物种（敏捷长臂猿、白掌长臂猿和合趾猿）的23个个体的2.2 kb基因进行了观察，总共观察到了24个单倍型。我们发现了五次古老的基因内重组的遗迹，这些重组发生在大约公元 100 年。 2-700万年前，通过系统发育网络分析。 A 和 B 等位基因之间的合并时间估计早于合趾猴和普通长臂猿谱系的分歧（约 8 MYA）。这确立了ABO血型基因的不同等位基因谱系在长臂猿祖先物种中长期共存，并加强了该基因的非中性进化。 (C) 2009 Elsevier Inc. 保留所有权利。
The primate ABO blood group gene encodes a glycosyl transferase (either A or B type), and is known to have large coalescence times among the allelic lineages in human. We determined nucleotide sequences of ca. 2.2 kb of this gene for 23 individuals of three gibbon species (agile gibbon, white-handed gibbon, and siamang), and observed a total of 24 haplotypes. We found relics of five ancient intragenic recombinations, occurred during ca. 2-7 million years ago, through a phylogenetic network analysis. The coalescence time between A and B alleles estimate precede the divergence (ca. 8 MYA) of siamang and common gibbon lineages. This establishes the coexistence of divergent allelic lineages of the ABO blood group gene for a long period in the ancestral gibbon species, and strengthens the non-neutral evolution for this gene. (C) 2009 Elsevier Inc. All rights reserved.