Neurobehavioural changes in patients following brain tumour: patients and relatives perspective
Neurobehavioural changes in patients following brain tumour: patients and relatives perspective
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DOI：
10.1007/s00520-014-2291-3
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发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Yagueez, L.
中科院分区：
文献类型：
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作者：
Gregg, N.;Arber, A.;Yagueez, L.
对脑肿瘤后患者和亲属的行为和性格变化经历进行了评估，以确定这些变化是否在额叶肿瘤患者及其亲属的经历中更为突出，作为评估是否需要对这些变化进行适当的支持和管理的第一步，这些变化对社会功能有重大影响，并最终改善生活质量。患者和亲属在额叶系统行为量表上对患者目前的冷漠、去抑制和执行功能障碍水平进行评分。患者还完成了医院焦虑和抑郁量表。分析了28例额叶肿瘤患者及其24名亲属和27例非额叶肿瘤患者及其25名亲属的数据，额叶肿瘤患者在所有额叶系统相关行为方面的自我评价显著高于非额叶肿瘤患者。额叶肿瘤患者中报告临床困难程度的患者数量明显更多。额叶肿瘤患者的亲属的评分显着高于非额叶肿瘤患者的亲属的冷漠。然而，无论肿瘤位置如何，至少40%的患者和亲属报告了临床显著水平的冷漠和执行功能障碍。额叶肿瘤患者的临床焦虑水平明显高于非额叶肿瘤患者，对脑肿瘤患者及其亲属的行为和个性改变给予支持和管理，无论肿瘤位置如何，都是最合适的。
Patients and relatives experiences of behavioural and personality changes following brain tumour were assessed to determine whether these changes are more prominent in the experience of patients with frontal tumours and their relatives as a first step to evaluate the need to develop appropriate support and management of such changes, which have a substantial impact on social functioning, and ultimately to improve quality of life.Patients and relatives rated the patients' current levels of apathy, disinhibition and executive dysfunction on the Frontal Systems Behaviour Scale. Patients also completed the Hospital Anxiety and Depression Scale. The data from 28 patients with frontal tumours and 24 of their relatives, and 27 patients with nonfrontal tumours and 25 of their relatives, were analysed.Patients with frontal tumours rated themselves significantly higher than patients with nonfrontal tumours on all frontal systems-related behaviours. The number of patients reporting clinical levels of difficulty was significantly greater in patients with frontal tumours for disinhibition. The ratings of relatives of patients with frontal tumours were significantly higher than those of relatives of patients with nonfrontal tumours for apathy. Clinically significant levels of apathy and executive dysfunction were however reported by at least 40 % of patients and relatives regardless of tumour location. Clinical levels of anxiety were reported by significantly more patients with frontal tumours than those with nonfrontal tumours.Support and management of behavioural and personality change for patients with brain tumours and their relatives, regardless of tumour location, would be most appropriate.