Smoking cessation may present a positive impact on mandibular bone quality and periodontitis-related bone loss:: A study in rats
Smoking cessation may present a positive impact on mandibular bone quality and periodontitis-related bone loss:: A study in rats
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DOI：
10.1902/jop.2005.76.4.520
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发表时间：
2005-04-01
影响因子：
4.3
通讯作者：
Nociti, FH
中科院分区：
文献类型：
--
作者：
César-Neto, JB;Benatti, BB;Nociti, FH
背景：先前已有研究表明，吸烟（CSI）会增加结扎性牙周炎患者的骨质流失。在本研究中，我们检验了中断吸烟暴露会逆转CSI对下颌骨质量和牙周炎相关骨质流失的影响的假设。方法：将53只Wistar大鼠随机分为两组：第一组：对照组，N = 16；第二组：结扎前83天CSI， N = 17；第三组：结扎前90天和结扎后60天的CSI， N = 20。结扎后60天处死动物，取下颌骨，立即x线摄影进行光密度分析。骨量丢失进行组织学评估。结果：两种情况下，CSI均未影响未结扎部位（P < 0.05）；全试验期间吸入烟雾显著增加结扎牙骨丢失（P < 0.05）。此外，在对照组和戒烟组之间，结扎牙齿的骨质流失水平相似(0.90 +/- 0.33 mm；0.96±0.32 mm(2)；1.64 +/- 0.65 mm(2)；组1、组2、组3)。放射学上，连续暴露于香烟烟雾中可显著降低骨密度（1、2和3组分别为1.74 +/- 0.38铝当量[Al eq]、1.74 +/- 0.14 Al eq和0.68 +/- 0.10 Al eq）。结论：在本研究范围内，可以假设CSI可能会增加结扎性牙周炎的骨质流失，并对下颌骨质量产生负面影响。此外，戒烟似乎可以逆转其对下颌骨的影响，因此，可能具有临床意义。
Background: It has been previously shown that cigarette smoke inhalation (CSI) enhances bone loss in ligature-induced periodontitis. In this study, the hypothesis that the interruption of smoke exposure would reverse the impact of CSI on mandibular bone quality and periodontitis-related bone loss was tested.Methods: Fifty-three Wistar rats were randomly assigned to one of the following groups: group 1: control, N = 16; group 2: 83 days of CSI prior to ligature placement, N = 17; or group 3: 90 days of CSI before and 60 days after ligature placement, N = 20. Animals were sacrificed 60 days after ligature placement, the jaws removed and immediately radiographed for photodensitometry analysis. Bone loss was histometrically evaluated.Results: CSI did not affect unligated sites in either condition (P > 0.05); however, smoke inhalation during the whole experimental period significantly enhanced bone loss in ligated teeth (P < 0.05). Moreover, similar levels of bone loss were observed for ligated teeth between the control and cessation groups (0.90 +/- 0.33 mm(2); 0.96 +/- 0.32 mm(2); 1.64 +/- 0.65 mm(2); groups 1, 2 and 3, respectively). Radiographically, continuous exposure to cigarette smoke promoted a significantly reduced bone density (1.74 +/- 0.38 aluminum equivalence [Al eq]; 1.74 +/- 0.14 Al eq; and 0.68 +/- 0.10 Al eq for groups 1, 2, and 3, respectively).Conclusions: Within the limits of the present investigation, it can be assumed that CSI may enhance bone loss in ligature-induced periodontitis, and negatively impact mandibular bone quality. Additionally, smoke exposure cessation seems to reverse its impact on mandibular bone, and, therefore, may be of clinical relevance.