Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study
Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study
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DOI：
10.1542/peds.108.3.e50
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发表时间：
2001-09-01
期刊：
影响因子：
8
通讯作者：
Shea, S
中科院分区：
文献类型：
--
作者：
Talmud, PJ;Berglund, L;Shea, S
目标.检测儿童与其父母相比的基因型：表型关联。4个关键基因位点的变异，即脂蛋白脂酶（LPL S447 X），肝脂肪酶（HL-480 C> T），胆固醇酯转运蛋白（CETP TaqIB）和载脂蛋白CIII在哥伦比亚大学生物标记物研究中，对儿童（n = 495）及其父母（n = 353）进行了检测，1994年至1998年，成绩。与西班牙裔受试者相比，非西班牙裔白色受试者中HL-480 C> T和APOC 3 - 455 T> C和-482 C> T（但不包括LPL S447 X或CETP TaqIB）的罕见等位基因频率显著较低。总体而言，在成人中看到的基因型效应在儿童中较弱，尽管看到了类似的趋势。在检查体脂对儿童基因型效应的影响时，HL-480 C> T：皮褶相互作用之和显著。所有的基因型都与成人的血脂水平有明确的关系，但在他们的孩子中的影响较弱，除非身体脂肪的压力。
Objectives. To examine the genotype: phenotype association in children compared with their parents.Methods. Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C> T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T> C and -482C> T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998.Results. The frequencies of the rare alleles of the HL -480C> T and APOC3 -455T> C and -482C> T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C> T: sum of skinfold interaction.Conclusions. All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat.