Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period
Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period
复制标题
DOI：
10.3174/ajnr.a4513
复制
发表时间：
2016-02-01
影响因子：
3.5
通讯作者：
Shirato, H.
中科院分区：
文献类型：
--
作者：
Fujima, N.;Yoshida, D.;Shirato, H.
应用伪连续ASL对41例头颈部鳞状细胞癌进行了评价。在治疗前和治疗早期计算定量肿瘤血流量。治疗失败组治疗前肿瘤血流量明显低于局部对照组。肿瘤血流的百分比变化与肿瘤体积的百分比变化相结合的使用具有较高的诊断准确性，用于预测局部control.Background和Purpose的治疗反应的评估在非手术治疗，肿瘤血流提供了功能信息的肿瘤，这是不同于形态信息，如肿瘤体积。本研究的目的是评估肿瘤的血流值的诊断价值，头颈部鳞状细胞癌patients.Materials和方法：41例头颈部鳞状细胞癌患者进行评估，使用伪连续动脉自旋标记。所有患者在治疗前和治疗早期定量计算肿瘤血流量，并计算两者之间肿瘤血流量的百分比变化。在治疗早期，根据肿瘤体积缩小率，我们将患者分为疾病稳定组和部分缓解组进行亚组分析。结果：失败组治疗前肿瘤血流量明显低于局部对照组（P < 0. 05），而局部控制组治疗后肿瘤血流量明显低于局部控制组（P < 0. 05）。在疾病稳定患者的亚组分析中，局部对照组的肿瘤血流量百分比变化显著大于失败组（由于肿瘤血流量较治疗前值增加）。此外，在部分缓解患者中，局部对照组的肿瘤血流量百分比变化显著小于失败组（由于肿瘤血流量较治疗前值降低）。局部对照组或失败组治疗前肿瘤血流的准确性为0.83，联合应用治疗早期肿瘤血流变化百分比和肿瘤体积变化百分比的准确性为0.93。结论：假连续动脉自旋标记法获得的肿瘤血流可用于局部对照的判断。联合应用肿瘤血流变化百分比和肿瘤体积诊断准确率特别高。
Forty-one patients with head and neck squamous cell carcinoma were evaluated by using pseudocontinuous ASL. Quantitative tumor blood flow was calculated at the pretreatment and the early treatment periods. Pretreatment tumor blood flow in patients in the treatment failure group was significantly lower than that in patients in the local control group. The use of the percentage change of tumor blood flow combined with the percentage change of tumor volume had high diagnostic accuracy for predicting local control.BACKGROUND AND PURPOSE: For the assessment of the treatment response in non-surgical treatment, tumor blood flow provides the functional information of the tumor which is different from the morphological information such as tumor volume. The purpose of this study was to evaluate the diagnostic value of tumor blood flow values obtained by pseudocontinuous arterial spin-labeling in patients with head and neck squamous cell carcinoma.MATERIALS AND METHODS: Forty-one patients with head and neck squamous cell carcinoma were evaluated by using pseudocontinuous arterial spin-labeling. Quantitative tumor blood flow was calculated at the pretreatment and the early treatment periods in all the patients, and the percentage change of tumor blood flow between the two was calculated. At the early treatment period, based on their tumor volume reduction rate, we divided the patients into stable disease and partial response groups for a subgroup analysis. The local control or failure was confirmed either by histopathology or by radiologic evaluation within the follow-up.RESULTS: Pretreatment tumor blood flow in patients in the failure group was significantly lower than that in patients in the local control group. In the subgroup analysis of patients with stable disease, the percentage change of tumor blood flow was significantly larger (due to the tumor blood flow increase from pretreatment value) in the local control group than in the failure group. In addition, in patients with a partial response, the percentage change of tumor blood flow was significantly smaller (due to the tumor blood flow decrease from the pretreatment value) in the local control group than in the failure group. The accuracy for determination of the local control group or the failure group in pretreatment tumor blood flow was 0.83 and that in the combination use of the percentage change of tumor blood flow and tumor volume in the early treatment period was 0.93.CONCLUSIONS: Tumor blood flow obtained by pseudocontinuous arterial spin-labeling can be useful for the determination of local control. The combined use of the percentage change of tumor blood flow and tumor volume had particularly high diagnostic accuracy.