Encoding strategies dissociate prefrontal activity from working memory demand
Encoding strategies dissociate prefrontal activity from working memory demand
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DOI：
10.1016/s0896-6273(02)01171-6
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发表时间：
2003-01-23
期刊：
影响因子：
16.2
通讯作者：
Owen, AM
中科院分区：
文献类型：
--
作者：
Bor, D;Duncan, J;Owen, AM
通常认为，前额叶皮层在组织和控制工作记忆内容中起重要作用。在某些情况下，有效的重组可以降低任务难度，这意味着额叶活动和基本记忆需求之间的分离。在一个空间工作记忆任务中，我们研究了当材料可以被重组成更高层次的组或块时，表现的改善。与非结构化序列相比，结构化序列鼓励重组和分块。尽管结构化序列更容易记忆，但事件相关功能磁共振成像（fMRI）显示，侧额叶皮层的激活增加，尤其是在记忆编码过程中。结果表明，即使当记忆需求减少时，将工作记忆内容组织成更高层次的块与前额叶活动增加有关。
It is often proposed that prefrontal cortex is important in organization and control of working memory contents. In some cases, effective reorganization can decrease task difficulty, implying a dissociation between frontal activity and basic memory demand. In a spatial working memory task, we studied the improvement of performance that occurs when materials can be reorganized into higher level groups or chunks. Structured sequences, encouraging reorganization and chunking, were compared with unstructured sequences. Though structured sequences were easier to remember, event-related functional magnetic resonance imaging (fMRI) showed increased activation of lateral frontal cortex, in particular during memory encoding. The results show that, even when memory demand decreases, organization of working memory contents into higher level chunks is associated with increased prefrontal activity.