DAP10- and DAP12-associated receptors in innate immunity.
DAP10- and DAP12-associated receptors in innate immunity.
复制标题
DOI：
10.1111/j.1600-065x.2008.00720.x
复制
发表时间：
2009-01
影响因子：
8.7
通讯作者：
Lanier LL
中科院分区：
文献类型：
--
作者：
Lanier LL
DAP 10和DAP 12信号转导亚基在进化中高度保守，并与造血细胞中的受体大家族相关，所述造血细胞包括树突细胞、浆细胞样树突细胞、嗜中性粒细胞、嗜碱性粒细胞、嗜酸性粒细胞、肥大细胞、单核细胞、巨噬细胞、自然杀伤细胞和一些B和T细胞。一些受体能够与DAP 10或DAP 12结合，这有助于独特的细胞内信号传导功能。对缺乏这些信号亚基的人类和小鼠的研究为DAP 10和DAP 12的生理功能提供了令人惊讶的见解，表明它们可以激活或抑制免疫反应。DAP 10-和DAP 12-相关受体已显示识别宿主编码的配体和微生物病原体编码的配体，表明它们在先天免疫应答中起重要作用。
The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.